Component

Creatine ethyl ester

Creatine ethyl ester. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Serum creatinine was higher with creatine ethyl ester than with monohydrate or placebo at the measured post-baseline visits.

    Creatine ethyl ester → Serum creatinine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"}
    experimental_model
    Seven-week randomized double-blind comparison plus resistance training
    exposure
    Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance
    limitations
    The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    30 previously non-resistance-trained men
    plain_language
    A formulation can change the creatinine marker; this trial alone does not establish the mechanism or diagnose kidney injury.
    primary_references
    [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    tissue_or_cell_type
    Serum and muscle metabolites, body composition and performance
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1101–1112

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven-week randomized double-blind comparison plus resistance training · source_derived_draft · unverified_draft

    ### creatine-ethyl-ester-creatinine Serum creatinine was higher with creatine ethyl ester than with monohydrate or placebo at the measured post-baseline visits. Condition category: biomarker_context nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A formulation can change the creatinine marker; this trial alone does not establish the mechanism or diagnose kidney injury. organism: 30 previously non-resistance-trained men tissue_or_cell_type: Serum and muscle metabolites, body composition and performance experimental_model: Seven-week randomized double-blind comparison plus resistance training limitations: The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes. exposure: Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance evidence_span: {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"} [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    Complete structured claim and evidence

  2. Both creatine formulations increased muscle total creatine versus placebo, with no significant difference between formulations; performance and body-composition changes did not significantly differ between groups.

    Creatine ethyl ester → Skeletal-muscle total creatine content source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"}
    experimental_model
    Seven-week randomized double-blind comparison plus resistance training
    exposure
    Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance
    limitations
    The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    30 previously non-resistance-trained men
    plain_language
    Ethyl ester did not show the claimed advantage in the measured outcomes.
    primary_references
    [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    tissue_or_cell_type
    Serum and muscle metabolites, body composition and performance

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1114–1125

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven-week randomized double-blind comparison plus resistance training · source_derived_draft · unverified_draft

    ### creatine-ethyl-ester-no-superiority Both creatine formulations increased muscle total creatine versus placebo, with no significant difference between formulations; performance and body-composition changes did not significantly differ between groups. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Ethyl ester did not show the claimed advantage in the measured outcomes. organism: 30 previously non-resistance-trained men tissue_or_cell_type: Serum and muscle metabolites, body composition and performance experimental_model: Seven-week randomized double-blind comparison plus resistance training limitations: The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes. exposure: Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance evidence_span: {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"} [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards