{"id":"dd991fd3-4619-5af9-90a8-7b775277c75d","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-ethyl-ester-no-superiority","predicate":"did_not_outperform","statement":"Both creatine formulations increased muscle total creatine versus placebo, with no significant difference between formulations; performance and body-composition changes did not significantly differ between groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"abbc8346-af1b-5289-ad34-6a044f4b9b10","mechanism_event_label":"Ethyl ester did not show the claimed advantage in the measured outcomes.","subject":{"id":"ab3fe8ad-9cba-5d22-9481-2400db4d1ea9","slug":"creatine-ethyl-ester","display_name":"Creatine ethyl ester","entity_type_key":"small_molecule"},"object":{"id":"3967d176-4a04-5f81-b264-b57cd5114890","slug":"muscle-total-creatine","display_name":"Skeletal-muscle total creatine content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"abbc8346-af1b-5289-ad34-6a044f4b9b10","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-ethyl-ester-no-superiority-event","event_type":"observed_intervention","label":"Ethyl ester did not show the claimed advantage in the measured outcomes.","description":"Both creatine formulations increased muscle total creatine versus placebo, with no significant difference between formulations; performance and body-composition changes did not significantly differ between groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ab3fe8ad-9cba-5d22-9481-2400db4d1ea9","slug":"creatine-ethyl-ester","display_name":"Creatine ethyl ester","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3967d176-4a04-5f81-b264-b57cd5114890","slug":"muscle-total-creatine","display_name":"Skeletal-muscle total creatine content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/19228401.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Seven-week randomized double-blind comparison plus resistance training","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"30 previously non-resistance-trained men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Ethyl ester did not show the claimed advantage in the measured outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum and muscle metabolites, body composition and performance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bdd4d61d-4851-5641-8339-34fd3c256d13","evidence_kind":"source_excerpt","locator":"Lines 1114-1125","start_line":1114,"end_line":1125,"excerpt":"### creatine-ethyl-ester-no-superiority\nBoth creatine formulations increased muscle total creatine versus placebo, with no significant difference between formulations; performance and body-composition changes did not significantly differ between groups.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Ethyl ester did not show the claimed advantage in the measured outcomes.\norganism: 30 previously non-resistance-trained men\ntissue_or_cell_type: Serum and muscle metabolites, body composition and performance\nexperimental_model: Seven-week randomized double-blind comparison plus resistance training\nlimitations: The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes.\nexposure: Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/19228401.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114\"}\n[creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6","model_system":"Seven-week randomized double-blind comparison plus resistance training","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70358046-c5c3-5e9a-9fc9-eb01c3fff88b","stable_key":"import-44737fa3-b335-53f4-a644-b9878d4416ac","title":"Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"548237d3e98a73a7dc02181807921fdd8b902adcee46248792258a761593eda9","revision_id":"88738255-8028-52fb-9c12-0fe92d8ce367","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}