Component

Serum creatinine concentration

Independent biological entity. Read linked claims for experimental scope and context.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Ten of fourteen patients with lactic acidosis during metformin treatment had significant metformin accumulation, generally because metformin was not withdrawn despite conditions affecting its renal elimination, and serum creatinine correlated positively with plasma metformin.

    Serum creatinine concentration → Plasma metformin exposure source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/metformin-research/7555503.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c960785146be30aa07921ceef25600c044dd421566e708cdc5c45bffccb0e301", "start_char": 0, "end_char": 2221, "text_sha256": "c960785146be30aa07921ceef25600c044dd421566e708cdc5c45bffccb0e301"}
    experimental_model
    Plasma metformin measurement by HPLC in 14 people with lactic acidosis during metformin treatment
    exposure
    Chronic metformin with intercurrent renal failure
    limitations
    A case series in an intensive-care setting. It argues against a simple dose-toxicity relationship; the numbers are small.
    nutrient_topic
    Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. · Metformin
    organism
    Human
    plain_language
    When the kidneys fail and the drug is not stopped, it builds up.
    primary_references
    [metformin-p7555503] Role of metformin accumulation in metformin-associated lactic acidosis. (1995). https://pubmed.ncbi.nlm.nih.gov/7555503/ DOI: 10.2337/diacare.18.6.779
    tissue_or_cell_type
    Whole body
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Metformin: transport, molecular targets, gut mechanisms and nutrient interactions (2026-09-19) · lines 1425–1436

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Plasma metformin measurement by HPLC in 14 people with lactic acidosis during metformin treatment · source_derived_draft · unverified_draft

    ### metformin-accumulation-lactic-acidosis Ten of fourteen patients with lactic acidosis during metformin treatment had significant metformin accumulation, generally because metformin was not withdrawn despite conditions affecting its renal elimination, and serum creatinine correlated positively with plasma metformin. Condition category: machinery_impairment nutrient_topic: Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. plain_language: When the kidneys fail and the drug is not stopped, it builds up. organism: Human tissue_or_cell_type: Whole body experimental_model: Plasma metformin measurement by HPLC in 14 people with lactic acidosis during metformin treatment limitations: A case series in an intensive-care setting. It argues against a simple dose-toxicity relationship; the numbers are small. exposure: Chronic metformin with intercurrent renal failure evidence_span: {"source_cache": "artifacts/metformin-research/7555503.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c960785146be30aa07921ceef25600c044dd421566e708cdc5c45bffccb0e301", "start_char": 0, "end_char": 2221, "text_sha256": "c960785146be30aa07921ceef25600c044dd421566e708cdc5c45bffccb0e301"} [metformin-p7555503] Role of metformin accumulation in metformin-associated lactic acidosis. (1995). https://pubmed.ncbi.nlm.nih.gov/7555503/ DOI: 10.2337/diacare.18.6.779
    Complete structured claim and evidence

What acts on it

  1. Serum creatinine was higher with creatine ethyl ester than with monohydrate or placebo at the measured post-baseline visits.

    Creatine ethyl ester → Serum creatinine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"}
    experimental_model
    Seven-week randomized double-blind comparison plus resistance training
    exposure
    Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance
    limitations
    The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    30 previously non-resistance-trained men
    plain_language
    A formulation can change the creatinine marker; this trial alone does not establish the mechanism or diagnose kidney injury.
    primary_references
    [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    tissue_or_cell_type
    Serum and muscle metabolites, body composition and performance
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1101–1112

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven-week randomized double-blind comparison plus resistance training · source_derived_draft · unverified_draft

    ### creatine-ethyl-ester-creatinine Serum creatinine was higher with creatine ethyl ester than with monohydrate or placebo at the measured post-baseline visits. Condition category: biomarker_context nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A formulation can change the creatinine marker; this trial alone does not establish the mechanism or diagnose kidney injury. organism: 30 previously non-resistance-trained men tissue_or_cell_type: Serum and muscle metabolites, body composition and performance experimental_model: Seven-week randomized double-blind comparison plus resistance training limitations: The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes. exposure: Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance evidence_span: {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"} [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    Complete structured claim and evidence

  2. TRPSS did not find a statistically significant difference in its primary creatinine trajectory endpoint; the 72-hour estimate was -0.57 mg/dL, 95% CI -1.18 to 0.04.

    Thiamine (vitamin B1) → Serum creatinine concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    88 treated patients with septic shock.
    exposure
    Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.
    limitations
    ICU-free days favored thiamine as a secondary outcome; kidney replacement, severe AKI and mortality differences were not significant.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    The renal-protection trial left an uncertain estimate rather than proving benefit.
    primary_references
    [b1-trpss2023] Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial (2023). https://pubmed.ncbi.nlm.nih.gov/37364280/ DOI: 10.1164/rccm.202301-0034oc
    tissue_or_cell_type
    Serum/clinical kidney endpoints

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1660–1670

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 88 treated patients with septic shock. · source_derived_draft · unverified_draft

    ### b1-trpss-creatinine-null TRPSS did not find a statistically significant difference in its primary creatinine trajectory endpoint; the 72-hour estimate was -0.57 mg/dL, 95% CI -1.18 to 0.04. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The renal-protection trial left an uncertain estimate rather than proving benefit. organism: Homo sapiens tissue_or_cell_type: Serum/clinical kidney endpoints experimental_model: 88 treated patients with septic shock. limitations: ICU-free days favored thiamine as a secondary outcome; kidney replacement, severe AKI and mortality differences were not significant. exposure: Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence. [b1-trpss2023] Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial (2023). https://pubmed.ncbi.nlm.nih.gov/37364280/ DOI: 10.1164/rccm.202301-0034oc
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards