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It argues against a simple dose-toxicity relationship; the numbers are small.\nexposure: Chronic metformin with intercurrent renal failure\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/7555503.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c960785146be30aa07921ceef25600c044dd421566e708cdc5c45bffccb0e301\", \"start_char\": 0, \"end_char\": 2221, \"text_sha256\": \"c960785146be30aa07921ceef25600c044dd421566e708cdc5c45bffccb0e301\"}\n[metformin-p7555503] Role of metformin accumulation in metformin-associated lactic acidosis. (1995). https://pubmed.ncbi.nlm.nih.gov/7555503/ DOI: 10.2337/diacare.18.6.779","model_system":"Plasma metformin measurement by HPLC in 14 people with lactic acidosis during metformin treatment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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