{"id":"997d025b-59d8-5edc-b5bd-9aa3bc405e60","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-creatinine-loss","predicate":"excretion_reflects_loss_of","statement":"Creatinine excretion represents continuing loss from the creatine/phosphocreatine pool, which is replaced by diet and/or endogenous synthesis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fb630404-3ecf-5d5c-89fa-0f7076f5e966","mechanism_event_label":"The pool needs replenishment because some material continually leaves as creatinine.","subject":{"id":"9c25f59f-e020-5dbb-b39b-90ad59525d84","slug":"creatinine","display_name":"Creatinine","entity_type_key":"small_molecule"},"object":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"fb630404-3ecf-5d5c-89fa-0f7076f5e966","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-creatinine-loss-event","event_type":"biochemical_relationship","label":"The pool needs replenishment because some material continually leaves as creatinine.","description":"Creatinine excretion represents continuing loss from the creatine/phosphocreatine pool, which is replaced by diet and/or endogenous synthesis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c081984a-e118-582f-ac46-6a767f8f0bf2","slug":"phosphocreatine","display_name":"Phosphocreatine","entity_type_key":"small_molecule"},"role":"pool_component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9c25f59f-e020-5dbb-b39b-90ad59525d84","slug":"creatinine","display_name":"Creatinine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/19017728.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee\", \"start_char\": 0, \"end_char\": 1599, \"text_sha256\": \"8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat feeding, isolated hepatocytes and in-vivo hepatic balance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Creatine-fed versus creatine-free conditions; guanidinoacetate and methionine substrate experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Biochemical premise of the rat synthesis paper, not a new quantitative human turnover measurement or a direct measure of tissue stores.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The pool needs replenishment because some material continually leaves as creatinine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p19017728] Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. (2009). https://pubmed.ncbi.nlm.nih.gov/19017728/ DOI: 10.1152/ajpendo.90547.2008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney, liver, plasma and isolated hepatocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"56db9f17-c3e7-5f1e-9d48-5c2e3d14541c","evidence_kind":"source_excerpt","locator":"Lines 256-267","start_line":256,"end_line":267,"excerpt":"### creatine-creatinine-loss\nCreatinine excretion represents continuing loss from the creatine/phosphocreatine pool, which is replaced by diet and/or endogenous synthesis.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The pool needs replenishment because some material continually leaves as creatinine.\norganism: Rats\ntissue_or_cell_type: Kidney, liver, plasma and isolated hepatocytes\nexperimental_model: Rat feeding, isolated hepatocytes and in-vivo hepatic balance\nlimitations: Biochemical premise of the rat synthesis paper, not a new quantitative human turnover measurement or a direct measure of tissue stores.\nexposure: Creatine-fed versus creatine-free conditions; guanidinoacetate and methionine substrate experiments\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/19017728.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee\", \"start_char\": 0, \"end_char\": 1599, \"text_sha256\": \"8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee\"}\n[creatine-p19017728] Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. 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