Component

Delivery of CoQ biosynthetic intermediates to synthesis enzymes

Delivery of CoQ biosynthetic intermediates to synthesis enzymes. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Excess CoQ suppressed intermediate binding and the promoting effect of COQ8 in the reconstructed system.

    Ubiquinone → Delivery of CoQ biosynthetic intermediates to synthesis enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"}
    experimental_model
    Reconstructed-protein biochemistry, crystallography and mutagenesis
    exposure
    ATP-dependent pocket gating; excess final CoQ product
    limitations
    2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Ancestral tetrapod COQ8A/COQ8B and COQ metabolon
    plain_language
    The finished product can feed back on its own synthesis machinery.
    primary_references
    [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
    tissue_or_cell_type
    Lipid-intermediate delivery

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 372–383

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reconstructed-protein biochemistry, crystallography and mutagenesis · source_derived_draft · unverified_draft

    ### coq10-coq-feedback Excess CoQ suppressed intermediate binding and the promoting effect of COQ8 in the reconstructed system. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The finished product can feed back on its own synthesis machinery. organism: Ancestral tetrapod COQ8A/COQ8B and COQ metabolon tissue_or_cell_type: Lipid-intermediate delivery experimental_model: Reconstructed-protein biochemistry, crystallography and mutagenesis limitations: 2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria. exposure: ATP-dependent pocket gating; excess final CoQ product evidence_span: {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"} [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
    Complete structured claim and evidence

  2. COQ7:COQ9 assemblies deformed membranes in simulations, suggesting a route for hydrophobic precursor access.

    Human CoQ hydroxylase / COQ7 → Delivery of CoQ biosynthetic intermediates to synthesis enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/36306796.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5", "start_char": 0, "end_char": 1049, "text_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5"}
    experimental_model
    Structure, lipid binding and molecular dynamics
    exposure
    Lipid-, substrate- and NADH-bound complexes
    limitations
    Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Human COQ7 and COQ9
    plain_language
    Getting the precursor out of the membrane may be part of how the enzyme pair works.
    primary_references
    [coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. (2022). https://pubmed.ncbi.nlm.nih.gov/36306796/ DOI: 10.1016/j.molcel.2022.10.003
    tissue_or_cell_type
    Membrane-associated biosynthesis complex

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 294–305

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Structure, lipid binding and molecular dynamics · source_derived_draft · unverified_draft

    ### coq10-coq7-membrane-model COQ7:COQ9 assemblies deformed membranes in simulations, suggesting a route for hydrophobic precursor access. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Getting the precursor out of the membrane may be part of how the enzyme pair works. organism: Human COQ7 and COQ9 tissue_or_cell_type: Membrane-associated biosynthesis complex experimental_model: Structure, lipid binding and molecular dynamics limitations: Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology. exposure: Lipid-, substrate- and NADH-bound complexes evidence_span: {"source_cache": "artifacts/coq10-research/36306796.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5", "start_char": 0, "end_char": 1049, "text_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5"} [coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. (2022). https://pubmed.ncbi.nlm.nih.gov/36306796/ DOI: 10.1016/j.molcel.2022.10.003
    Complete structured claim and evidence

  3. Reconstructed COQ8A promoted CoQ production through ATPase-linked handling of insoluble pathway intermediates.

    Reconstructed ancestral tetrapod COQ8A → Delivery of CoQ biosynthetic intermediates to synthesis enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"}
    experimental_model
    Reconstructed-protein biochemistry, crystallography and mutagenesis
    exposure
    ATP-dependent pocket gating; excess final CoQ product
    limitations
    2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Ancestral tetrapod COQ8A/COQ8B and COQ metabolon
    plain_language
    The helper moves intermediates between synthesis enzymes rather than simply adding more raw material.
    primary_references
    [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
    tissue_or_cell_type
    Lipid-intermediate delivery

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 346–357

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reconstructed-protein biochemistry, crystallography and mutagenesis · source_derived_draft · unverified_draft

    ### coq10-coq8a-chaperone Reconstructed COQ8A promoted CoQ production through ATPase-linked handling of insoluble pathway intermediates. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The helper moves intermediates between synthesis enzymes rather than simply adding more raw material. organism: Ancestral tetrapod COQ8A/COQ8B and COQ metabolon tissue_or_cell_type: Lipid-intermediate delivery experimental_model: Reconstructed-protein biochemistry, crystallography and mutagenesis limitations: 2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria. exposure: ATP-dependent pocket gating; excess final CoQ product evidence_span: {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"} [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
    Complete structured claim and evidence

  4. Reconstructed COQ8B promoted CoQ production through ATPase-linked handling of insoluble pathway intermediates.

    Reconstructed ancestral tetrapod COQ8B → Delivery of CoQ biosynthetic intermediates to synthesis enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"}
    experimental_model
    Reconstructed-protein biochemistry, crystallography and mutagenesis
    exposure
    ATP-dependent pocket gating; excess final CoQ product
    limitations
    2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Ancestral tetrapod COQ8A/COQ8B and COQ metabolon
    plain_language
    The helper moves intermediates between synthesis enzymes rather than simply adding more raw material.
    primary_references
    [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
    tissue_or_cell_type
    Lipid-intermediate delivery

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 359–370

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reconstructed-protein biochemistry, crystallography and mutagenesis · source_derived_draft · unverified_draft

    ### coq10-coq8b-chaperone Reconstructed COQ8B promoted CoQ production through ATPase-linked handling of insoluble pathway intermediates. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The helper moves intermediates between synthesis enzymes rather than simply adding more raw material. organism: Ancestral tetrapod COQ8A/COQ8B and COQ metabolon tissue_or_cell_type: Lipid-intermediate delivery experimental_model: Reconstructed-protein biochemistry, crystallography and mutagenesis limitations: 2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria. exposure: ATP-dependent pocket gating; excess final CoQ product evidence_span: {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"} [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards