Component
Reconstructed ancestral tetrapod COQ8A
Reconstructed ancestral tetrapod COQ8A. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Reconstructed COQ8A promoted CoQ production through ATPase-linked handling of insoluble pathway intermediates.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"}
- experimental_model
- Reconstructed-protein biochemistry, crystallography and mutagenesis
- exposure
- ATP-dependent pocket gating; excess final CoQ product
- limitations
- 2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- Ancestral tetrapod COQ8A/COQ8B and COQ metabolon
- plain_language
- The helper moves intermediates between synthesis enzymes rather than simply adding more raw material.
- primary_references
- [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
- tissue_or_cell_type
- Lipid-intermediate delivery
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 346–357
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reconstructed-protein biochemistry, crystallography and mutagenesis · source_derived_draft · unverified_draft
### coq10-coq8a-chaperone Reconstructed COQ8A promoted CoQ production through ATPase-linked handling of insoluble pathway intermediates. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The helper moves intermediates between synthesis enzymes rather than simply adding more raw material. organism: Ancestral tetrapod COQ8A/COQ8B and COQ metabolon tissue_or_cell_type: Lipid-intermediate delivery experimental_model: Reconstructed-protein biochemistry, crystallography and mutagenesis limitations: 2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria. exposure: ATP-dependent pocket gating; excess final CoQ product evidence_span: {"source_cache": "artifacts/coq10-research/42525751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632", "start_char": 0, "end_char": 1058, "text_sha256": "b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632"} [coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. (2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.