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(2026). https://pubmed.ncbi.nlm.nih.gov/42525751/ DOI: 10.1126/sciadv.aeg1124","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Lipid-intermediate delivery","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8f327a92-db53-5688-a18e-93963a9ff448","evidence_kind":"source_excerpt","locator":"Lines 346-357","start_line":346,"end_line":357,"excerpt":"### coq10-coq8a-chaperone\nReconstructed COQ8A promoted CoQ production through ATPase-linked handling of insoluble pathway intermediates.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The helper moves intermediates between synthesis enzymes rather than simply adding more raw material.\norganism: Ancestral tetrapod COQ8A/COQ8B and COQ metabolon\ntissue_or_cell_type: Lipid-intermediate delivery\nexperimental_model: Reconstructed-protein biochemistry, crystallography and mutagenesis\nlimitations: 2026 reconstructed system using short-chain intermediates; do not assign all kinetics directly to intact human mitochondria.\nexposure: ATP-dependent pocket gating; excess final CoQ product\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/42525751.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632\", \"start_char\": 0, \"end_char\": 1058, \"text_sha256\": \"b7a49b25f09323a11c782afbdbff069e95429ed28e0ce2da5519abcbaa76c632\"}\n[coq10-p42525751] COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. 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