Component

Human CoQ hydroxylase / COQ7

Human CoQ hydroxylase / COQ7. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. COQ7:COQ9 assemblies deformed membranes in simulations, suggesting a route for hydrophobic precursor access.

    Human CoQ hydroxylase / COQ7 → Delivery of CoQ biosynthetic intermediates to synthesis enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/36306796.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5", "start_char": 0, "end_char": 1049, "text_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5"}
    experimental_model
    Structure, lipid binding and molecular dynamics
    exposure
    Lipid-, substrate- and NADH-bound complexes
    limitations
    Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Human COQ7 and COQ9
    plain_language
    Getting the precursor out of the membrane may be part of how the enzyme pair works.
    primary_references
    [coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. (2022). https://pubmed.ncbi.nlm.nih.gov/36306796/ DOI: 10.1016/j.molcel.2022.10.003
    tissue_or_cell_type
    Membrane-associated biosynthesis complex

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 294–305

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Structure, lipid binding and molecular dynamics · source_derived_draft · unverified_draft

    ### coq10-coq7-membrane-model COQ7:COQ9 assemblies deformed membranes in simulations, suggesting a route for hydrophobic precursor access. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Getting the precursor out of the membrane may be part of how the enzyme pair works. organism: Human COQ7 and COQ9 tissue_or_cell_type: Membrane-associated biosynthesis complex experimental_model: Structure, lipid binding and molecular dynamics limitations: Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology. exposure: Lipid-, substrate- and NADH-bound complexes evidence_span: {"source_cache": "artifacts/coq10-research/36306796.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5", "start_char": 0, "end_char": 1049, "text_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5"} [coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. (2022). https://pubmed.ncbi.nlm.nih.gov/36306796/ DOI: 10.1016/j.molcel.2022.10.003
    Complete structured claim and evidence

What acts on it

  1. COQ9 enhanced substrate binding in the hydrophobic channel of COQ7.

    Human COQ9 lipid-binding protein → Human CoQ hydroxylase / COQ7 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/36306796.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5", "start_char": 0, "end_char": 1049, "text_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5"}
    experimental_model
    Structure, lipid binding and molecular dynamics
    exposure
    Lipid-, substrate- and NADH-bound complexes
    limitations
    Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Human COQ7 and COQ9
    plain_language
    A lipid-binding helper presents a difficult-to-access substrate to a separate enzyme.
    primary_references
    [coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. (2022). https://pubmed.ncbi.nlm.nih.gov/36306796/ DOI: 10.1016/j.molcel.2022.10.003
    tissue_or_cell_type
    Membrane-associated biosynthesis complex

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 281–292

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Structure, lipid binding and molecular dynamics · source_derived_draft · unverified_draft

    ### coq10-coq7-coq9 COQ9 enhanced substrate binding in the hydrophobic channel of COQ7. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A lipid-binding helper presents a difficult-to-access substrate to a separate enzyme. organism: Human COQ7 and COQ9 tissue_or_cell_type: Membrane-associated biosynthesis complex experimental_model: Structure, lipid binding and molecular dynamics limitations: Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology. exposure: Lipid-, substrate- and NADH-bound complexes evidence_span: {"source_cache": "artifacts/coq10-research/36306796.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5", "start_char": 0, "end_char": 1049, "text_sha256": "adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5"} [coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. (2022). https://pubmed.ncbi.nlm.nih.gov/36306796/ DOI: 10.1016/j.molcel.2022.10.003
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Purified COQ9 associated with lipids including CoQ and used a conserved surface to interact with COQ7.

    Human COQ9 lipid-binding protein → Ubiquinone source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/25339443.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5", "start_char": 0, "end_char": 1471, "text_sha256": "30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5"}
    experimental_model
    Mouse disease model, protein structure and lipid-binding assays
    exposure
    COQ9 R239X disease model and purified COQ9
    limitations
    Protein loss is not dietary CoQ shortage; lipid-presentation details include mechanistic inference.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Mouse Coq9 mutant and human COQ9 structure
    plain_language
    CoQ synthesis involves lipid handling as well as chemical reactions.
    primary_references
    [coq10-p25339443] Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. (2014). https://pubmed.ncbi.nlm.nih.gov/25339443/ DOI: 10.1073/pnas.1413128111
    tissue_or_cell_type
    COQ9-COQ7 interaction

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 307–318

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse disease model, protein structure and lipid-binding assays · source_derived_draft · unverified_draft

    ### coq10-coq9-binding Purified COQ9 associated with lipids including CoQ and used a conserved surface to interact with COQ7. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: CoQ synthesis involves lipid handling as well as chemical reactions. organism: Mouse Coq9 mutant and human COQ9 structure tissue_or_cell_type: COQ9-COQ7 interaction experimental_model: Mouse disease model, protein structure and lipid-binding assays limitations: Protein loss is not dietary CoQ shortage; lipid-presentation details include mechanistic inference. exposure: COQ9 R239X disease model and purified COQ9 evidence_span: {"source_cache": "artifacts/coq10-research/25339443.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5", "start_char": 0, "end_char": 1471, "text_sha256": "30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5"} [coq10-p25339443] Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. (2014). https://pubmed.ncbi.nlm.nih.gov/25339443/ DOI: 10.1073/pnas.1413128111
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards