{"id":"47d9707b-9d35-5abb-9410-9cd26a211613","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-coq9-binding","predicate":"binds","statement":"Purified COQ9 associated with lipids including CoQ and used a conserved surface to interact with COQ7.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"28c7591e-ad66-569a-8166-f31e9dc502f8","mechanism_event_label":"CoQ synthesis involves lipid handling as well as chemical reactions.","subject":{"id":"6d6ce345-77eb-50f1-a70a-02ac660d9a5b","slug":"coq9","display_name":"Human COQ9 lipid-binding protein","entity_type_key":"protein"},"object":{"id":"ae9544c3-df78-54f8-80e7-5b643e5ba1cf","slug":"ubiquinone","display_name":"Ubiquinone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"28c7591e-ad66-569a-8166-f31e9dc502f8","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-coq9-binding-event","event_type":"biochemical_relationship","label":"CoQ synthesis involves lipid handling as well as chemical reactions.","description":"Purified COQ9 associated with lipids including CoQ and used a conserved surface to interact with COQ7.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"63c70ccb-61ea-54ba-b639-071379f72096","slug":"coq7","display_name":"Human CoQ hydroxylase / COQ7","entity_type_key":"protein"},"role":"protein_partner","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6d6ce345-77eb-50f1-a70a-02ac660d9a5b","slug":"coq9","display_name":"Human COQ9 lipid-binding protein","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae9544c3-df78-54f8-80e7-5b643e5ba1cf","slug":"ubiquinone","display_name":"Ubiquinone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/25339443.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5\", \"start_char\": 0, \"end_char\": 1471, \"text_sha256\": \"30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse disease model, protein structure and lipid-binding assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"COQ9 R239X disease model and purified COQ9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protein loss is not dietary CoQ shortage; lipid-presentation details include mechanistic inference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mouse Coq9 mutant and human COQ9 structure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"CoQ synthesis involves lipid handling as well as chemical reactions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p25339443] Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. (2014). https://pubmed.ncbi.nlm.nih.gov/25339443/ DOI: 10.1073/pnas.1413128111","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"COQ9-COQ7 interaction","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9a28d225-a3fa-5414-aee5-8fb1b23a44de","evidence_kind":"source_excerpt","locator":"Lines 307-318","start_line":307,"end_line":318,"excerpt":"### coq10-coq9-binding\nPurified COQ9 associated with lipids including CoQ and used a conserved surface to interact with COQ7.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: CoQ synthesis involves lipid handling as well as chemical reactions.\norganism: Mouse Coq9 mutant and human COQ9 structure\ntissue_or_cell_type: COQ9-COQ7 interaction\nexperimental_model: Mouse disease model, protein structure and lipid-binding assays\nlimitations: Protein loss is not dietary CoQ shortage; lipid-presentation details include mechanistic inference.\nexposure: COQ9 R239X disease model and purified COQ9\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/25339443.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5\", \"start_char\": 0, \"end_char\": 1471, \"text_sha256\": \"30231d534c146d800ac3035cced0e6ce0ba810d871b40967a5483a19ee90f1a5\"}\n[coq10-p25339443] Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. 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