{"id":"d8fd23eb-3b80-5772-a013-15dc71adc755","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-coq7-membrane-model","predicate":"with_coq9_may_facilitate","statement":"COQ7:COQ9 assemblies deformed membranes in simulations, suggesting a route for hydrophobic precursor access.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f25863c5-e5d2-5cac-abfc-b5859963fac9","mechanism_event_label":"Getting the precursor out of the membrane may be part of how the enzyme pair works.","subject":{"id":"63c70ccb-61ea-54ba-b639-071379f72096","slug":"coq7","display_name":"Human CoQ hydroxylase / COQ7","entity_type_key":"protein"},"object":{"id":"e45b9de8-075b-50b8-87ff-c613836b30f8","slug":"coq-intermediate-delivery","display_name":"Delivery of CoQ biosynthetic intermediates to synthesis enzymes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f25863c5-e5d2-5cac-abfc-b5859963fac9","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-coq7-membrane-model-event","event_type":"biochemical_relationship","label":"Getting the precursor out of the membrane may be part of how the enzyme pair works.","description":"COQ7:COQ9 assemblies deformed membranes in simulations, suggesting a route for hydrophobic precursor access.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6d6ce345-77eb-50f1-a70a-02ac660d9a5b","slug":"coq9","display_name":"Human COQ9 lipid-binding protein","entity_type_key":"protein"},"role":"partner","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"63c70ccb-61ea-54ba-b639-071379f72096","slug":"coq7","display_name":"Human CoQ hydroxylase / COQ7","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e45b9de8-075b-50b8-87ff-c613836b30f8","slug":"coq-intermediate-delivery","display_name":"Delivery of CoQ biosynthetic intermediates to synthesis enzymes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/36306796.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5\", \"start_char\": 0, \"end_char\": 1049, \"text_sha256\": \"adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Structure, lipid binding and molecular dynamics","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lipid-, substrate- and NADH-bound complexes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human COQ7 and COQ9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Getting the precursor out of the membrane may be part of how the enzyme pair works.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. (2022). https://pubmed.ncbi.nlm.nih.gov/36306796/ DOI: 10.1016/j.molcel.2022.10.003","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Membrane-associated biosynthesis complex","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bb817660-d480-54dc-80b3-a7e8cccaf279","evidence_kind":"source_excerpt","locator":"Lines 294-305","start_line":294,"end_line":305,"excerpt":"### coq10-coq7-membrane-model\nCOQ7:COQ9 assemblies deformed membranes in simulations, suggesting a route for hydrophobic precursor access.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Getting the precursor out of the membrane may be part of how the enzyme pair works.\norganism: Human COQ7 and COQ9\ntissue_or_cell_type: Membrane-associated biosynthesis complex\nexperimental_model: Structure, lipid binding and molecular dynamics\nlimitations: Structural and simulation evidence; proposed membrane-deformation route is not directly measured dietary physiology.\nexposure: Lipid-, substrate- and NADH-bound complexes\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/36306796.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5\", \"start_char\": 0, \"end_char\": 1049, \"text_sha256\": \"adcddf90628bba3d14303fb8ec894bcece68fdf5b5591bbabb8f6bcef638d2e5\"}\n[coq10-p36306796] Structure and functionality of a multimeric human COQ7:COQ9 complex. 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