Component

Chloride

Chloride nutrient topic. The independently modeled chemical species is chloride ion (Cl−). Dietary shortage, gastrointestinal or renal losses, blood concentration, intracellular gradients and genetic transport defects are different states. Sodium chloride, potassium chloride and chloride-rich intravenous fluids retain their accompanying ions and routes.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. A seven-month-old infant fed chloride-deficient formula developed hypochloremic alkalosis.

    Chloride → Chloride-depletion metabolic alkalosis source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chloride-research/7293908.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84", "start_char": 0, "end_char": 458, "text_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84"}
    experimental_model
    Infant case and formula correction
    exposure
    Chloride-deficient formula replaced with adequate formula
    limitations
    Uncontrolled historical case; formula replacement is not a universal dose-response experiment.
    nutrient_topic
    Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
    organism
    Human
    plain_language
    A true dietary shortage was documented under this unusual feeding condition.
    primary_references
    [chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/
    tissue_or_cell_type
    Diet, growth and blood chemistry
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 796–807

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Infant case and formula correction · source_derived_draft · unverified_draft

    ### chloride-formula-alkalosis A seven-month-old infant fed chloride-deficient formula developed hypochloremic alkalosis. Condition category: nutrient_deficiency nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: A true dietary shortage was documented under this unusual feeding condition. organism: Human tissue_or_cell_type: Diet, growth and blood chemistry experimental_model: Infant case and formula correction limitations: Uncontrolled historical case; formula replacement is not a universal dose-response experiment. exposure: Chloride-deficient formula replaced with adequate formula evidence_span: {"source_cache": "artifacts/chloride-research/7293908.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84", "start_char": 0, "end_char": 458, "text_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84"} [chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/
    Complete structured claim and evidence

  2. Both infants resumed normal weight gain after switching to a formula with adequate chloride.

    Chloride → Infant weight gain source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chloride-research/7354566.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4", "start_char": 0, "end_char": 418, "text_sha256": "3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4"}
    experimental_model
    Two infant cases after a formula manufacturing error
    exposure
    Severely chloride-deficient soy formula replaced
    limitations
    Case reports; not a population prevalence estimate.
    nutrient_topic
    Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
    organism
    Human
    plain_language
    Correcting the feeding problem restored growth in these cases.
    primary_references
    [chloride-p7354566] Failure to thrive and metabolic alkalosis. Adverse effects of a chloride-deficient formula in two infants. (1980). https://pubmed.ncbi.nlm.nih.gov/7354566/ DOI: 10.1001/jama.1980.03300360040024
    tissue_or_cell_type
    Nutrition and growth
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 822–833

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two infant cases after a formula manufacturing error · source_derived_draft · unverified_draft

    ### chloride-formula-growth Both infants resumed normal weight gain after switching to a formula with adequate chloride. Condition category: nutrient_deficiency nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: Correcting the feeding problem restored growth in these cases. organism: Human tissue_or_cell_type: Nutrition and growth experimental_model: Two infant cases after a formula manufacturing error limitations: Case reports; not a population prevalence estimate. exposure: Severely chloride-deficient soy formula replaced evidence_span: {"source_cache": "artifacts/chloride-research/7354566.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4", "start_char": 0, "end_char": 418, "text_sha256": "3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4"} [chloride-p7354566] Failure to thrive and metabolic alkalosis. Adverse effects of a chloride-deficient formula in two infants. (1980). https://pubmed.ncbi.nlm.nih.gov/7354566/ DOI: 10.1001/jama.1980.03300360040024
    Complete structured claim and evidence

  3. Hyperreninemia and hyperaldosteronism accompanied the deficient-formula case and normalized after adequate feeding.

    Chloride → Renin–aldosterone system activation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chloride-research/7293908.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84", "start_char": 0, "end_char": 458, "text_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84"}
    experimental_model
    Infant case and formula correction
    exposure
    Chloride-deficient formula replaced with adequate formula
    limitations
    Uncontrolled historical case; formula replacement is not a universal dose-response experiment.
    nutrient_topic
    Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
    organism
    Human
    plain_language
    The body’s salt-conserving hormone system responded to the shortage.
    primary_references
    [chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/
    tissue_or_cell_type
    Diet, growth and blood chemistry
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 809–820

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Infant case and formula correction · source_derived_draft · unverified_draft

    ### chloride-formula-hormones Hyperreninemia and hyperaldosteronism accompanied the deficient-formula case and normalized after adequate feeding. Condition category: nutrient_deficiency nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: The body’s salt-conserving hormone system responded to the shortage. organism: Human tissue_or_cell_type: Diet, growth and blood chemistry experimental_model: Infant case and formula correction limitations: Uncontrolled historical case; formula replacement is not a universal dose-response experiment. exposure: Chloride-deficient formula replaced with adequate formula evidence_span: {"source_cache": "artifacts/chloride-research/7293908.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84", "start_char": 0, "end_char": 458, "text_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84"} [chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards