{"id":"b806d7ab-f2aa-5fde-bc7a-fc4d119c3302","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-formula-growth","predicate":"repletion_associated_with","statement":"Both infants resumed normal weight gain after switching to a formula with adequate chloride.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"57e5554a-bb63-5235-b325-ace8720f4ca7","mechanism_event_label":"Correcting the feeding problem restored growth in these cases.","subject":{"id":"6a844eb8-a21b-54ed-8e57-9d830a16312b","slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"},"object":{"id":"191f6b1a-7902-530c-84a3-068cc6fdd801","slug":"infant-weight-gain","display_name":"Infant weight gain","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"57e5554a-bb63-5235-b325-ace8720f4ca7","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-formula-growth-event","event_type":"observed_intervention","label":"Correcting the feeding problem restored growth in these cases.","description":"Both infants resumed normal weight gain after switching to a formula with adequate chloride.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6a844eb8-a21b-54ed-8e57-9d830a16312b","slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"191f6b1a-7902-530c-84a3-068cc6fdd801","slug":"infant-weight-gain","display_name":"Infant weight gain","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/7354566.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4\", \"start_char\": 0, \"end_char\": 418, \"text_sha256\": \"3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two infant cases after a formula manufacturing error","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Severely chloride-deficient soy formula replaced","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Case reports; not a population prevalence estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Correcting the feeding problem restored growth in these cases.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p7354566] Failure to thrive and metabolic alkalosis. Adverse effects of a chloride-deficient formula in two infants. (1980). https://pubmed.ncbi.nlm.nih.gov/7354566/ DOI: 10.1001/jama.1980.03300360040024","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Nutrition and growth","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"7f7c432a-3736-5cc8-8311-1c186178c570","evidence_kind":"source_excerpt","locator":"Lines 822-833","start_line":822,"end_line":833,"excerpt":"### chloride-formula-growth\nBoth infants resumed normal weight gain after switching to a formula with adequate chloride.\nCondition category: nutrient_deficiency\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Correcting the feeding problem restored growth in these cases.\norganism: Human\ntissue_or_cell_type: Nutrition and growth\nexperimental_model: Two infant cases after a formula manufacturing error\nlimitations: Case reports; not a population prevalence estimate.\nexposure: Severely chloride-deficient soy formula replaced\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/7354566.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4\", \"start_char\": 0, \"end_char\": 418, \"text_sha256\": \"3b7b6f5d5a9768b20ea47cf913f35928464109148730676363c19c4ba39fb2c4\"}\n[chloride-p7354566] Failure to thrive and metabolic alkalosis. 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