Component
Chloride-depletion metabolic alkalosis
Chloride-depletion metabolic alkalosis. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A seven-month-old infant fed chloride-deficient formula developed hypochloremic alkalosis.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/chloride-research/7293908.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84", "start_char": 0, "end_char": 458, "text_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84"}
- experimental_model
- Infant case and formula correction
- exposure
- Chloride-deficient formula replaced with adequate formula
- limitations
- Uncontrolled historical case; formula replacement is not a universal dose-response experiment.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Human
- plain_language
- A true dietary shortage was documented under this unusual feeding condition.
- primary_references
- [chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/
- tissue_or_cell_type
- Diet, growth and blood chemistry
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 796–807
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Infant case and formula correction · source_derived_draft · unverified_draft
### chloride-formula-alkalosis A seven-month-old infant fed chloride-deficient formula developed hypochloremic alkalosis. Condition category: nutrient_deficiency nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: A true dietary shortage was documented under this unusual feeding condition. organism: Human tissue_or_cell_type: Diet, growth and blood chemistry experimental_model: Infant case and formula correction limitations: Uncontrolled historical case; formula replacement is not a universal dose-response experiment. exposure: Chloride-deficient formula replaced with adequate formula evidence_span: {"source_cache": "artifacts/chloride-research/7293908.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84", "start_char": 0, "end_char": 458, "text_sha256": "a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84"} [chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/
Complete structured claim and evidenceOral KCl corrected induced chloride-depletion alkalosis while plasma volume, body weight and filtration remained reduced.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/chloride-research/2450456.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7", "start_char": 0, "end_char": 1348, "text_sha256": "3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7"}
- experimental_model
- Human depletion–repletion balance experiment
- exposure
- Furosemide plus restricted NaCl; oral KCl repletion over 36 hours
- limitations
- Loss-associated depletion; KCl supplies potassium too. Mechanism does not imply self-treatment or apply to every alkalosis.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Human men
- plain_language
- Restoring volume was not necessary for correction in this experiment.
- primary_references
- [chloride-p2450456] On the mechanism by which chloride corrects metabolic alkalosis in man. (1988). https://pubmed.ncbi.nlm.nih.gov/2450456/ DOI: 10.1016/0002-9343(88)90265-3
- tissue_or_cell_type
- Kidney and systemic acid–base balance
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 835–846
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human depletion–repletion balance experiment · source_derived_draft · unverified_draft
### chloride-repletion-alkalosis Oral KCl corrected induced chloride-depletion alkalosis while plasma volume, body weight and filtration remained reduced. Condition category: nutrient_deficiency nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: Restoring volume was not necessary for correction in this experiment. organism: Human men tissue_or_cell_type: Kidney and systemic acid–base balance experimental_model: Human depletion–repletion balance experiment limitations: Loss-associated depletion; KCl supplies potassium too. Mechanism does not imply self-treatment or apply to every alkalosis. exposure: Furosemide plus restricted NaCl; oral KCl repletion over 36 hours evidence_span: {"source_cache": "artifacts/chloride-research/2450456.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7", "start_char": 0, "end_char": 1348, "text_sha256": "3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7"} [chloride-p2450456] On the mechanism by which chloride corrects metabolic alkalosis in man. (1988). https://pubmed.ncbi.nlm.nih.gov/2450456/ DOI: 10.1016/0002-9343(88)90265-3
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.