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Mechanism does not imply self-treatment or apply to every alkalosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Restoring volume was not necessary for correction in this experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p2450456] On the mechanism by which chloride corrects metabolic alkalosis in man. (1988). https://pubmed.ncbi.nlm.nih.gov/2450456/ DOI: 10.1016/0002-9343(88)90265-3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney and systemic acid–base balance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a8ddccfd-e91f-5a28-b42f-2187680ff411","evidence_kind":"source_excerpt","locator":"Lines 835-846","start_line":835,"end_line":846,"excerpt":"### chloride-repletion-alkalosis\nOral KCl corrected induced chloride-depletion alkalosis while plasma volume, body weight and filtration remained reduced.\nCondition category: nutrient_deficiency\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Restoring volume was not necessary for correction in this experiment.\norganism: Human men\ntissue_or_cell_type: Kidney and systemic acid–base balance\nexperimental_model: Human depletion–repletion balance experiment\nlimitations: Loss-associated depletion; KCl supplies potassium too. Mechanism does not imply self-treatment or apply to every alkalosis.\nexposure: Furosemide plus restricted NaCl; oral KCl repletion over 36 hours\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/2450456.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7\", \"start_char\": 0, \"end_char\": 1348, \"text_sha256\": \"3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7\"}\n[chloride-p2450456] On the mechanism by which chloride corrects metabolic alkalosis in man. (1988). https://pubmed.ncbi.nlm.nih.gov/2450456/ DOI: 10.1016/0002-9343(88)90265-3","model_system":"Human depletion–repletion balance experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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