{"id":"517585c5-352f-53ae-a746-533350484b69","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-formula-hormones","predicate":"deficiency_associated_with","statement":"Hyperreninemia and hyperaldosteronism accompanied the deficient-formula case and normalized after adequate feeding.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"edeb155f-aa0a-5263-905b-ddd6ce5847d0","mechanism_event_label":"The body’s salt-conserving hormone system responded to the shortage.","subject":{"id":"6a844eb8-a21b-54ed-8e57-9d830a16312b","slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"},"object":{"id":"db7eb17a-a2a8-5534-9625-e5202d93e566","slug":"renin-aldosterone-activation","display_name":"Renin–aldosterone system activation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"edeb155f-aa0a-5263-905b-ddd6ce5847d0","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-formula-hormones-event","event_type":"observed_intervention","label":"The body’s salt-conserving hormone system responded to the shortage.","description":"Hyperreninemia and hyperaldosteronism accompanied the deficient-formula case and normalized after adequate feeding.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6a844eb8-a21b-54ed-8e57-9d830a16312b","slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"db7eb17a-a2a8-5534-9625-e5202d93e566","slug":"renin-aldosterone-activation","display_name":"Renin–aldosterone system activation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/7293908.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84\", \"start_char\": 0, \"end_char\": 458, \"text_sha256\": \"a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Infant case and formula correction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chloride-deficient formula replaced with adequate formula","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Uncontrolled historical case; formula replacement is not a universal dose-response experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The body’s salt-conserving hormone system responded to the shortage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Diet, growth and blood chemistry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"addf9465-4c8c-5df9-8027-87198579a555","evidence_kind":"source_excerpt","locator":"Lines 809-820","start_line":809,"end_line":820,"excerpt":"### chloride-formula-hormones\nHyperreninemia and hyperaldosteronism accompanied the deficient-formula case and normalized after adequate feeding.\nCondition category: nutrient_deficiency\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The body’s salt-conserving hormone system responded to the shortage.\norganism: Human\ntissue_or_cell_type: Diet, growth and blood chemistry\nexperimental_model: Infant case and formula correction\nlimitations: Uncontrolled historical case; formula replacement is not a universal dose-response experiment.\nexposure: Chloride-deficient formula replaced with adequate formula\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/7293908.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84\", \"start_char\": 0, \"end_char\": 458, \"text_sha256\": \"a4d85273187d5fba7fc6f5c38bda3da041dc4751715a0e65c995ba6898650a84\"}\n[chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/","model_system":"Infant case and formula correction","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chloride-p7293908] Metabolic effects of chloride-deficient formula. (1981). https://pubmed.ncbi.nlm.nih.gov/7293908/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1c2070d5-9f15-5945-b325-d0b49a32c04b","stable_key":"import-4df6a932-097e-563a-91fe-5dceec471ffd","title":"Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e32e796f293a3287c6b8f4394881db94cc741ba96e3166e44da2dd14f208f645","revision_id":"8d5fd8ef-db54-5198-a368-23329a02d81b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}