Component

C. zeylanicum aqueous extract in the 2010 rat/cell study

C. zeylanicum aqueous extract in the 2010 rat/cell study. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

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How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The aqueous extract increased glucose uptake in 3T3-L1 adipocytes.

    C. zeylanicum aqueous extract in the 2010 rat/cell study → Mouse adipocyte glucose uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"}
    experimental_model
    STZ-diabetic rat treatment and mouse adipocyte experiments
    exposure
    Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day
    limitations
    Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Mouse
    plain_language
    The cultured mouse fat cells took up more glucose.
    primary_references
    [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    tissue_or_cell_type
    3T3-L1 adipocytes

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 506–517

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · STZ-diabetic rat treatment and mouse adipocyte experiments · source_derived_draft · unverified_draft

    ### ceylon-mouse-glucose-uptake The aqueous extract increased glucose uptake in 3T3-L1 adipocytes. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cultured mouse fat cells took up more glucose. organism: Mouse tissue_or_cell_type: 3T3-L1 adipocytes experimental_model: STZ-diabetic rat treatment and mouse adipocyte experiments limitations: Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans. exposure: Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day evidence_span: {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"} [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    Complete structured claim and evidence

  2. The aqueous extract increased GLUT4 translocation in 3T3-L1 adipocytes.

    C. zeylanicum aqueous extract in the 2010 rat/cell study → Mouse GLUT4 movement toward or into the cell surface source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"}
    experimental_model
    STZ-diabetic rat treatment and mouse adipocyte experiments
    exposure
    Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day
    limitations
    Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Mouse
    plain_language
    Mouse fat cells moved more glucose transporters toward the cell surface.
    primary_references
    [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    tissue_or_cell_type
    3T3-L1 adipocytes

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 493–504

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · STZ-diabetic rat treatment and mouse adipocyte experiments · source_derived_draft · unverified_draft

    ### ceylon-mouse-glut4 The aqueous extract increased GLUT4 translocation in 3T3-L1 adipocytes. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Mouse fat cells moved more glucose transporters toward the cell surface. organism: Mouse tissue_or_cell_type: 3T3-L1 adipocytes experimental_model: STZ-diabetic rat treatment and mouse adipocyte experiments limitations: Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans. exposure: Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day evidence_span: {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"} [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    Complete structured claim and evidence

  3. The aqueous extract increased GLUT4 expression in the treated diabetic rats.

    C. zeylanicum aqueous extract in the 2010 rat/cell study → Rat glucose transporter 4 / Slc2a4 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"}
    experimental_model
    STZ-diabetic rat treatment and mouse adipocyte experiments
    exposure
    Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day
    limitations
    Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Rat
    plain_language
    The rats produced more of a transporter involved in glucose uptake.
    primary_references
    [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    tissue_or_cell_type
    Brown adipose tissue and muscle

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 480–491

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · STZ-diabetic rat treatment and mouse adipocyte experiments · source_derived_draft · unverified_draft

    ### ceylon-rat-glut4 The aqueous extract increased GLUT4 expression in the treated diabetic rats. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The rats produced more of a transporter involved in glucose uptake. organism: Rat tissue_or_cell_type: Brown adipose tissue and muscle experimental_model: STZ-diabetic rat treatment and mouse adipocyte experiments limitations: Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans. exposure: Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day evidence_span: {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"} [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    Complete structured claim and evidence

  4. The aqueous extract increased UCP1 expression in the treated diabetic-rat tissue study.

    C. zeylanicum aqueous extract in the 2010 rat/cell study → Rat mitochondrial uncoupling protein 1 / Ucp1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"}
    experimental_model
    STZ-diabetic rat treatment and mouse adipocyte experiments
    exposure
    Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day
    limitations
    Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Rat
    plain_language
    The rat energy-handling machinery changed.
    primary_references
    [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    tissue_or_cell_type
    Brown adipose tissue and muscle

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 467–478

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · STZ-diabetic rat treatment and mouse adipocyte experiments · source_derived_draft · unverified_draft

    ### ceylon-rat-ucp1 The aqueous extract increased UCP1 expression in the treated diabetic-rat tissue study. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The rat energy-handling machinery changed. organism: Rat tissue_or_cell_type: Brown adipose tissue and muscle experimental_model: STZ-diabetic rat treatment and mouse adipocyte experiments limitations: Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans. exposure: Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day evidence_span: {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"} [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    Complete structured claim and evidence

In the sources

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