{"id":"8b313a37-f0d2-5786-b18b-7241cf76929c","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-rat-glut4","predicate":"increases","statement":"The aqueous extract increased GLUT4 expression in the treated diabetic rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bb2eee64-a39f-59f1-9c9e-6b101ca6a4f4","mechanism_event_label":"The rats produced more of a transporter involved in glucose uptake.","subject":{"id":"7b695090-83ff-5cc1-ac0e-6d3b84a97d45","slug":"ceylon-aqueous-2010","display_name":"C. zeylanicum aqueous extract in the 2010 rat/cell study","entity_type_key":"chemical_species"},"object":{"id":"b355feba-1bd3-55d6-9f12-54b9fbadfd58","slug":"rat-slc2a4","display_name":"Rat glucose transporter 4 / Slc2a4","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"bb2eee64-a39f-59f1-9c9e-6b101ca6a4f4","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-rat-glut4-event","event_type":"biochemical_relationship","label":"The rats produced more of a transporter involved in glucose uptake.","description":"The aqueous extract increased GLUT4 expression in the treated diabetic rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7b695090-83ff-5cc1-ac0e-6d3b84a97d45","slug":"ceylon-aqueous-2010","display_name":"C. zeylanicum aqueous extract in the 2010 rat/cell study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b355feba-1bd3-55d6-9f12-54b9fbadfd58","slug":"rat-slc2a4","display_name":"Rat glucose transporter 4 / Slc2a4","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/21150113.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9\", \"start_char\": 0, \"end_char\": 1075, \"text_sha256\": \"3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"STZ-diabetic rat treatment and mouse adipocyte experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The rats produced more of a transporter involved in glucose uptake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brown adipose tissue and muscle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b00855bf-c5af-5faf-8368-ef356c159307","evidence_kind":"source_excerpt","locator":"Lines 480-491","start_line":480,"end_line":491,"excerpt":"### ceylon-rat-glut4\nThe aqueous extract increased GLUT4 expression in the treated diabetic rats.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The rats produced more of a transporter involved in glucose uptake.\norganism: Rat\ntissue_or_cell_type: Brown adipose tissue and muscle\nexperimental_model: STZ-diabetic rat treatment and mouse adipocyte experiments\nlimitations: Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans.\nexposure: Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/21150113.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9\", \"start_char\": 0, \"end_char\": 1075, \"text_sha256\": \"3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9\"}\n[ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453","model_system":"STZ-diabetic rat treatment and mouse adipocyte experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3aed3c5b-8016-5e37-ad6f-9019d34d19eb","stable_key":"import-3d41d18a-e13a-59a0-a081-55bfcdd43e55","title":"Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"639b1d8dcff42f2cf1f00a7dc38202289b70213e37c357c375b1f5905d6cf832","revision_id":"9675eb03-ee34-5160-b928-46b6ca9d1ecc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}