Component

Mouse adipocyte glucose uptake

Mouse adipocyte glucose uptake. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The aqueous extract increased glucose uptake in 3T3-L1 adipocytes.

    C. zeylanicum aqueous extract in the 2010 rat/cell study → Mouse adipocyte glucose uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"}
    experimental_model
    STZ-diabetic rat treatment and mouse adipocyte experiments
    exposure
    Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day
    limitations
    Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Mouse
    plain_language
    The cultured mouse fat cells took up more glucose.
    primary_references
    [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    tissue_or_cell_type
    3T3-L1 adipocytes

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 506–517

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · STZ-diabetic rat treatment and mouse adipocyte experiments · source_derived_draft · unverified_draft

    ### ceylon-mouse-glucose-uptake The aqueous extract increased glucose uptake in 3T3-L1 adipocytes. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cultured mouse fat cells took up more glucose. organism: Mouse tissue_or_cell_type: 3T3-L1 adipocytes experimental_model: STZ-diabetic rat treatment and mouse adipocyte experiments limitations: Extract effects cannot be assigned to pure cinnamaldehyde or substituted for insulin in humans. exposure: Aqueous extract for 22 days in rats; effects reported above 30 mg/kg/day evidence_span: {"source_cache": "artifacts/ceylon-research/21150113.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9", "start_char": 0, "end_char": 1075, "text_sha256": "3a58afe3cd3cd503ea2fba0faeb90aee891bceab69a523e3a8c1de27ed9c04d9"} [ceylon-p21150113] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010). https://pubmed.ncbi.nlm.nih.gov/21150113/ DOI: 10.1271/bbb.100453
    Complete structured claim and evidence

  2. Lipoic acid increased glucose uptake in 3T3-L1 adipocytes; intracellular thiol modification or inhibition of the upstream oxidant response blocked stimulation.

    Lipoic acid → Mouse adipocyte glucose uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ala-research/12948866.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0440cb8edaf0213af3824367ee799d1a1916ed2340c9da99588d83c7581804b9", "start_char": 0, "end_char": 1489, "text_sha256": "0440cb8edaf0213af3824367ee799d1a1916ed2340c9da99588d83c7581804b9"}
    experimental_model
    Protein-thiol, phosphorylation and glucose-uptake assays
    exposure
    Alpha-lipoic-acid stimulation with redox/thiol inhibitors
    limitations
    Cell-culture redox signaling; not proof that lipoic acid invariably lowers oxidation in all settings.
    nutrient_topic
    Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
    organism
    Mouse
    plain_language
    The glucose response depended on the cell’s redox-signaling machinery.
    primary_references
    [ala-p12948866] Alpha-lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes. (2003). https://pubmed.ncbi.nlm.nih.gov/12948866/ DOI: 10.1016/s0006-2952(03)00395-2
    tissue_or_cell_type
    3T3-L1 adipocytes

    Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 962–973

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Protein-thiol, phosphorylation and glucose-uptake assays · source_derived_draft · unverified_draft

    ### ala-adipocyte-glucose Lipoic acid increased glucose uptake in 3T3-L1 adipocytes; intracellular thiol modification or inhibition of the upstream oxidant response blocked stimulation. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The glucose response depended on the cell’s redox-signaling machinery. organism: Mouse tissue_or_cell_type: 3T3-L1 adipocytes experimental_model: Protein-thiol, phosphorylation and glucose-uptake assays limitations: Cell-culture redox signaling; not proof that lipoic acid invariably lowers oxidation in all settings. exposure: Alpha-lipoic-acid stimulation with redox/thiol inhibitors evidence_span: {"source_cache": "artifacts/ala-research/12948866.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0440cb8edaf0213af3824367ee799d1a1916ed2340c9da99588d83c7581804b9", "start_char": 0, "end_char": 1489, "text_sha256": "0440cb8edaf0213af3824367ee799d1a1916ed2340c9da99588d83c7581804b9"} [ala-p12948866] Alpha-lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes. (2003). https://pubmed.ncbi.nlm.nih.gov/12948866/ DOI: 10.1016/s0006-2952(03)00395-2
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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