Component
Purified PDE4D preparation in the Townsend airway study
Purified PDE4D enzyme assay, separate from human airway tissue. The accessed abstract does not establish the species or splice variant of the enzyme preparation.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.
Experimental context and source evidence
- dose
- Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here
- duration
- Not specified in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Purified PDE4D and PLC beta enzyme preparations
- limitations
- Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Purified PDE4D and PLC beta enzyme preparations
- plain_language
- 6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.
- primary_references
- Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC
- route
- In vitro addition
- tissue
- Cell-free enzyme assays
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 195–204
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Purified PDE4D and PLC beta enzyme preparations · source_derived_draft · unverified_draft
## gingerols-6-pde4d 6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study. Model/species: Purified PDE4D and PLC beta enzyme preparations Tissue: Cell-free enzyme assays Exposure: Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here Route: In vitro addition Duration: Not specified in accessed abstract Limits: Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target. Primary reference: Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC Access: Primary PubMed abstract.
Complete structured claim and evidence8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.
Experimental context and source evidence
- dose
- Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here
- duration
- Not specified in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Purified PDE4D and PLC beta enzyme preparations
- limitations
- Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Purified PDE4D and PLC beta enzyme preparations
- plain_language
- 8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.
- primary_references
- Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC
- route
- In vitro addition
- tissue
- Cell-free enzyme assays
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 217–226
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Purified PDE4D and PLC beta enzyme preparations · source_derived_draft · unverified_draft
## gingerols-8-pde4d 8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study. Model/species: Purified PDE4D and PLC beta enzyme preparations Tissue: Cell-free enzyme assays Exposure: Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here Route: In vitro addition Duration: Not specified in accessed abstract Limits: Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target. Primary reference: Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.