{"id":"caa7ce00-1b66-5e12-ae93-f7c13eee989f","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-pde4d","predicate":"inhibits","statement":"8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b7642853-f4df-5c94-b0a7-b0ca334e303a","mechanism_event_label":"8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","subject":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"cf4f39a2-bd1d-5049-ab3a-9407f8501818","slug":"townsend-purified-pde4d-preparation","display_name":"Purified PDE4D preparation in the Townsend airway study","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b7642853-f4df-5c94-b0a7-b0ca334e303a","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-pde4d-event","event_type":"observed_relationship","label":"8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","description":"8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cf4f39a2-bd1d-5049-ab3a-9407f8501818","slug":"townsend-purified-pde4d-preparation","display_name":"Purified PDE4D preparation in the Townsend airway study","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified PDE4D and PLC beta enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Purified PDE4D and PLC beta enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"8-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. 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