{"id":"0e3102c0-e5d6-5da1-b8a0-9d69262729f7","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-pde4d","predicate":"inhibits","statement":"6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"847fbf9b-7c8a-52c2-bcc2-76ddbb5e4ec5","mechanism_event_label":"6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"cf4f39a2-bd1d-5049-ab3a-9407f8501818","slug":"townsend-purified-pde4d-preparation","display_name":"Purified PDE4D preparation in the Townsend airway study","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"847fbf9b-7c8a-52c2-bcc2-76ddbb5e4ec5","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-pde4d-event","event_type":"observed_relationship","label":"6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","description":"6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cf4f39a2-bd1d-5049-ab3a-9407f8501818","slug":"townsend-purified-pde4d-preparation","display_name":"Purified PDE4D preparation in the Townsend airway study","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified PDE4D and PLC beta enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Purified PDE4D and PLC beta enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cell-free enzyme assays","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bc19d886-0179-5c70-bc02-afda87fb3e78","evidence_kind":"source_excerpt","locator":"Lines 195-204","start_line":195,"end_line":204,"excerpt":"## gingerols-6-pde4d\n6-Gingerol inhibited the purified PDE4D preparation in the airway-mechanism study.\nModel/species: Purified PDE4D and PLC beta enzyme preparations\nTissue: Cell-free enzyme assays\nExposure: Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here\nRoute: In vitro addition\nDuration: Not specified in accessed abstract\nLimits: Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target.\nPrimary reference: Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC\nAccess: Primary PubMed abstract.","model_system":"Purified PDE4D and PLC beta enzyme preparations","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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