Component

Riboflavin transporter 2 / SLC52A2

Human RFVT2; older hRFT3 nomenclature is distinct from modern RFVT3.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Human tissue RT-PCR found strong SLC52A2 mRNA expression in brain and salivary gland.

    Riboflavin transporter 2 / SLC52A2 → Brain source_derived_draftungraded
    Experimental context and source evidence
    evidence_location
    Abstract; tissue RT-PCR
    experimental_model
    Human tissue RT-PCR panel
    exposure
    No nutrient intervention; tissue-expression survey.
    limitations
    mRNA abundance neither localizes the protein to a particular neural cell nor quantifies uptake.
    nutrient_topic
    Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
    organism
    Homo sapiens
    plain_language
    RFVT2 is expressed in tissues that require access to circulating riboflavin.
    primary_references
    [transport-rfvt2-2010] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. (2010). https://doi.org/10.3945/jn.110.122911 DOI: 10.3945/jn.110.122911
    tissue_or_cell_type
    Brain and salivary gland

    Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 163–174

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human tissue RT-PCR panel · source_derived_draft · unverified_draft

    ### transport-rfvt2-brain-expression Human tissue RT-PCR found strong SLC52A2 mRNA expression in brain and salivary gland. Condition category: normal nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: RFVT2 is expressed in tissues that require access to circulating riboflavin. organism: Homo sapiens tissue_or_cell_type: Brain and salivary gland experimental_model: Human tissue RT-PCR panel limitations: mRNA abundance neither localizes the protein to a particular neural cell nor quantifies uptake. exposure: No nutrient intervention; tissue-expression survey. evidence_location: Abstract; tissue RT-PCR [transport-rfvt2-2010] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. (2010). https://doi.org/10.3945/jn.110.122911 DOI: 10.3945/jn.110.122911
    Complete structured claim and evidence

  2. Human RFVT2 expression increased riboflavin uptake in HEK293 cells; uptake did not require extracellular sodium or chloride.

    Riboflavin transporter 2 / SLC52A2 → Riboflavin (vitamin B2) source_derived_draftungraded
    Experimental context and source evidence
    evidence_location
    Abstract; comparative HEK293 transport assays
    experimental_model
    Human RFVT2 expression and radiotracer uptake
    exposure
    Transient expression; extracellular-ion substitution.
    limitations
    Older name hRFT3 maps to SLC52A2, not SLC52A3; tissue mRNA enrichment is not transport flux.
    nutrient_topic
    Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
    organism
    Homo sapiens
    plain_language
    RFVT2 provides a route for riboflavin entry into cells.
    primary_references
    [transport-rfvt2-2010] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. (2010). https://doi.org/10.3945/jn.110.122911 DOI: 10.3945/jn.110.122911
    tissue_or_cell_type
    HEK293 cells
    transport_effect
    raises Expression increased riboflavin uptake in HEK293 cells.
    transport_pool
    the expressing cell Expression increased riboflavin uptake in HEK293 cells.

    Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 150–161

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human RFVT2 expression and radiotracer uptake · source_derived_draft · unverified_draft

    ### transport-rfvt2-influx Human RFVT2 expression increased riboflavin uptake in HEK293 cells; uptake did not require extracellular sodium or chloride. Condition category: normal nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: RFVT2 provides a route for riboflavin entry into cells. organism: Homo sapiens tissue_or_cell_type: HEK293 cells experimental_model: Human RFVT2 expression and radiotracer uptake limitations: Older name hRFT3 maps to SLC52A2, not SLC52A3; tissue mRNA enrichment is not transport flux. exposure: Transient expression; extracellular-ion substitution. evidence_location: Abstract; comparative HEK293 transport assays [transport-rfvt2-2010] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. (2010). https://doi.org/10.3945/jn.110.122911 DOI: 10.3945/jn.110.122911
    Complete structured claim and evidence

  3. Tagged human Riboflavin transporter 2 / SLC52A2 localized mainly in intracellular vesicles, with some basolateral expression in polarized Caco-2 and MDCK imaging experiments.

    Riboflavin transporter 2 / SLC52A2 → Intracellular vesicles source_derived_draftungraded
    Experimental context and source evidence
    evidence_location
    Live-cell imaging; historical RFT1/2/3 correspond to RFVT1/3/2
    experimental_model
    Live-cell confocal imaging of tagged transporter constructs
    exposure
    Expression of fluorescent transporter constructs.
    limitations
    Tagged overexpression in epithelial models; not a universal localization map across tissues.
    nutrient_topic
    Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
    organism
    Human proteins in human and canine cells
    plain_language
    The riboflavin transporters occupy different parts of polarized epithelial cells.
    primary_references
    [transport-localization-2011] Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. (2011). https://pubmed.ncbi.nlm.nih.gov/21854757/ DOI: 10.1016/j.bbamem.2011.08.004
    tissue_or_cell_type
    Polarized Caco-2 and MDCK cells

    Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 189–200

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Live-cell confocal imaging of tagged transporter constructs · source_derived_draft · unverified_draft

    ### transport-slc52a2-localization Tagged human Riboflavin transporter 2 / SLC52A2 localized mainly in intracellular vesicles, with some basolateral expression in polarized Caco-2 and MDCK imaging experiments. Condition category: normal nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The riboflavin transporters occupy different parts of polarized epithelial cells. organism: Human proteins in human and canine cells tissue_or_cell_type: Polarized Caco-2 and MDCK cells experimental_model: Live-cell confocal imaging of tagged transporter constructs limitations: Tagged overexpression in epithelial models; not a universal localization map across tissues. exposure: Expression of fluorescent transporter constructs. evidence_location: Live-cell imaging; historical RFT1/2/3 correspond to RFVT1/3/2 [transport-localization-2011] Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. (2011). https://pubmed.ncbi.nlm.nih.gov/21854757/ DOI: 10.1016/j.bbamem.2011.08.004
    Complete structured claim and evidence

  4. The child with compound SLC52A2 L123P/L339P variants had normal measured plasma riboflavin, FMN and FAD despite a transport-associated neurologic disorder.

    Riboflavin transporter 2 / SLC52A2 → Plasma riboflavin, FMN and FAD concentrations source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_location
    Table 3 and Methods/results
    experimental_model
    Single genetic case; plasma flavin assay
    exposure
    Pretreatment plasma measurements.
    limitations
    One case; normal plasma measurements are not direct measurements of neuronal flavin sufficiency.
    nutrient_topic
    Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
    organism
    Homo sapiens
    plain_language
    Normal plasma flavins did not exclude a cellular transport defect.
    primary_references
    [transport-slc52a2-disease-2012] Impaired riboflavin transport due to missense mutations in SLC52A2 causes Brown-Vialetto-Van Laere syndrome (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3470687/ DOI: 10.1007/s10545-012-9513-y
    tissue_or_cell_type
    Plasma and clinical nervous-system phenotype
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 451–462

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single genetic case; plasma flavin assay · source_derived_draft · unverified_draft

    ### transport-slc52a2-normal-plasma The child with compound SLC52A2 L123P/L339P variants had normal measured plasma riboflavin, FMN and FAD despite a transport-associated neurologic disorder. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Normal plasma flavins did not exclude a cellular transport defect. organism: Homo sapiens tissue_or_cell_type: Plasma and clinical nervous-system phenotype experimental_model: Single genetic case; plasma flavin assay limitations: One case; normal plasma measurements are not direct measurements of neuronal flavin sufficiency. exposure: Pretreatment plasma measurements. evidence_location: Table 3 and Methods/results [transport-slc52a2-disease-2012] Impaired riboflavin transport due to missense mutations in SLC52A2 causes Brown-Vialetto-Van Laere syndrome (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3470687/ DOI: 10.1007/s10545-012-9513-y
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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