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(2010). https://doi.org/10.3945/jn.110.122911 DOI: 10.3945/jn.110.122911","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HEK293 cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Expression increased riboflavin uptake in HEK293 cells.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Expression increased riboflavin uptake in HEK293 cells.","entity":null}],"evidence":[{"id":"4bffc54d-8cc7-5543-8c6a-30b108771b07","evidence_kind":"source_excerpt","locator":"Lines 150-161","start_line":150,"end_line":161,"excerpt":"### transport-rfvt2-influx\nHuman RFVT2 expression increased riboflavin uptake in HEK293 cells; uptake did not require extracellular sodium or chloride.\nCondition category: normal\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: RFVT2 provides a route for riboflavin entry into cells.\norganism: Homo sapiens\ntissue_or_cell_type: HEK293 cells\nexperimental_model: Human RFVT2 expression and radiotracer uptake\nlimitations: Older name hRFT3 maps to SLC52A2, not SLC52A3; tissue mRNA enrichment is not transport flux.\nexposure: Transient expression; extracellular-ion substitution.\nevidence_location: Abstract; comparative HEK293 transport assays\n[transport-rfvt2-2010] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. 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