Component
Intracellular vesicles
Membrane-bound uptake and processing compartments; individual vesicle identities depend on context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Tagged human Riboflavin transporter 2 / SLC52A2 localized mainly in intracellular vesicles, with some basolateral expression in polarized Caco-2 and MDCK imaging experiments.
Experimental context and source evidence
- evidence_location
- Live-cell imaging; historical RFT1/2/3 correspond to RFVT1/3/2
- experimental_model
- Live-cell confocal imaging of tagged transporter constructs
- exposure
- Expression of fluorescent transporter constructs.
- limitations
- Tagged overexpression in epithelial models; not a universal localization map across tissues.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Human proteins in human and canine cells
- plain_language
- The riboflavin transporters occupy different parts of polarized epithelial cells.
- primary_references
- [transport-localization-2011] Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. (2011). https://pubmed.ncbi.nlm.nih.gov/21854757/ DOI: 10.1016/j.bbamem.2011.08.004
- tissue_or_cell_type
- Polarized Caco-2 and MDCK cells
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 189–200
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Live-cell confocal imaging of tagged transporter constructs · source_derived_draft · unverified_draft
### transport-slc52a2-localization Tagged human Riboflavin transporter 2 / SLC52A2 localized mainly in intracellular vesicles, with some basolateral expression in polarized Caco-2 and MDCK imaging experiments. Condition category: normal nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The riboflavin transporters occupy different parts of polarized epithelial cells. organism: Human proteins in human and canine cells tissue_or_cell_type: Polarized Caco-2 and MDCK cells experimental_model: Live-cell confocal imaging of tagged transporter constructs limitations: Tagged overexpression in epithelial models; not a universal localization map across tissues. exposure: Expression of fluorescent transporter constructs. evidence_location: Live-cell imaging; historical RFT1/2/3 correspond to RFVT1/3/2 [transport-localization-2011] Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. (2011). https://pubmed.ncbi.nlm.nih.gov/21854757/ DOI: 10.1016/j.bbamem.2011.08.004
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.