Component
Brain
Brain tissue; individual neural cell types remain distinct.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Human tissue RT-PCR found strong SLC52A2 mRNA expression in brain and salivary gland.
Experimental context and source evidence
- evidence_location
- Abstract; tissue RT-PCR
- experimental_model
- Human tissue RT-PCR panel
- exposure
- No nutrient intervention; tissue-expression survey.
- limitations
- mRNA abundance neither localizes the protein to a particular neural cell nor quantifies uptake.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Homo sapiens
- plain_language
- RFVT2 is expressed in tissues that require access to circulating riboflavin.
- primary_references
- [transport-rfvt2-2010] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. (2010). https://doi.org/10.3945/jn.110.122911 DOI: 10.3945/jn.110.122911
- tissue_or_cell_type
- Brain and salivary gland
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 163–174
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human tissue RT-PCR panel · source_derived_draft · unverified_draft
### transport-rfvt2-brain-expression Human tissue RT-PCR found strong SLC52A2 mRNA expression in brain and salivary gland. Condition category: normal nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: RFVT2 is expressed in tissues that require access to circulating riboflavin. organism: Homo sapiens tissue_or_cell_type: Brain and salivary gland experimental_model: Human tissue RT-PCR panel limitations: mRNA abundance neither localizes the protein to a particular neural cell nor quantifies uptake. exposure: No nutrient intervention; tissue-expression survey. evidence_location: Abstract; tissue RT-PCR [transport-rfvt2-2010] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. (2010). https://doi.org/10.3945/jn.110.122911 DOI: 10.3945/jn.110.122911
Complete structured claim and evidenceRat SVCT2 tissue distribution included brain and eye, whereas SVCT1 distribution favored intestinal, kidney and liver epithelia.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Rat cDNA transporters expressed in Xenopus oocytes; mammalian tissue distribution
- exposure
- Tissue-distribution analysis
- limitations
- Primary abstract only; no inferred human kinetic constants.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Rattus norvegicus
- plain_language
- The two vitamin C transporters have different tissue distributions.
- primary_references
- [tsukaguchi1999] A family of mammalian Na+-dependent L-ascorbic acid transporters. (1999). https://pubmed.ncbi.nlm.nih.gov/10331392/ DOI: 10.1038/19986
- tissue_or_cell_type
- Brain, eye, intestine, kidney and liver
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 130–141
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat cDNA transporters expressed in Xenopus oocytes; mammalian tissue distribution · source_derived_draft · unverified_draft
### vc-transport-svct-distribution Rat SVCT2 tissue distribution included brain and eye, whereas SVCT1 distribution favored intestinal, kidney and liver epithelia. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The two vitamin C transporters have different tissue distributions. organism: Rattus norvegicus tissue_or_cell_type: Brain, eye, intestine, kidney and liver experimental_model: Rat cDNA transporters expressed in Xenopus oocytes; mammalian tissue distribution limitations: Primary abstract only; no inferred human kinetic constants. exposure: Tissue-distribution analysis cross_nutrient: false [tsukaguchi1999] A family of mammalian Na+-dependent L-ascorbic acid transporters. (1999). https://pubmed.ncbi.nlm.nih.gov/10331392/ DOI: 10.1038/19986
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.