{"id":"585c8025-609b-5914-8498-1282cd42e904","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct-distribution","predicate":"is-distributed-in","statement":"Rat SVCT2 tissue distribution included brain and eye, whereas SVCT1 distribution favored intestinal, kidney and liver epithelia.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ed760f72-86b8-5ef7-9252-b2e2019ca3c9","mechanism_event_label":"The two vitamin C transporters have different tissue distributions.","subject":{"id":"d8382cc1-953f-505d-8887-18b39504b0ec","slug":"rat-slc23a2","display_name":"Rat sodium-dependent vitamin C transporter 2 / Slc23a2","entity_type_key":"protein"},"object":{"id":"2fccfcb0-eb3f-5858-946a-e490adda6190","slug":"brain","display_name":"Brain","entity_type_key":"tissue"},"evidence_count":1,"mechanism_event":{"id":"ed760f72-86b8-5ef7-9252-b2e2019ca3c9","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct-distribution-event","event_type":"observed_intervention","label":"The two vitamin C transporters have different tissue distributions.","description":"Rat SVCT2 tissue distribution included brain and eye, whereas SVCT1 distribution favored intestinal, kidney and liver epithelia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4d59e1f0-d552-57a5-8241-2a5949cdd9a4","slug":"rat-slc23a1","display_name":"Rat sodium-dependent vitamin C transporter 1 / Slc23a1","entity_type_key":"protein"},"role":"comparison transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d8382cc1-953f-505d-8887-18b39504b0ec","slug":"rat-slc23a2","display_name":"Rat sodium-dependent vitamin C transporter 2 / Slc23a2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2fccfcb0-eb3f-5858-946a-e490adda6190","slug":"brain","display_name":"Brain","entity_type_key":"tissue"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat cDNA transporters expressed in Xenopus oocytes; mammalian tissue distribution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tissue-distribution analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary abstract only; no inferred human kinetic constants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The two vitamin C transporters have different tissue distributions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[tsukaguchi1999] A family of mammalian Na+-dependent L-ascorbic acid transporters. (1999). https://pubmed.ncbi.nlm.nih.gov/10331392/ DOI: 10.1038/19986","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain, eye, intestine, kidney and liver","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c08e4256-a837-5b19-8141-d58d610c1b2f","evidence_kind":"source_excerpt","locator":"Lines 130-141","start_line":130,"end_line":141,"excerpt":"### vc-transport-svct-distribution\nRat SVCT2 tissue distribution included brain and eye, whereas SVCT1 distribution favored intestinal, kidney and liver epithelia.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The two vitamin C transporters have different tissue distributions.\norganism: Rattus norvegicus\ntissue_or_cell_type: Brain, eye, intestine, kidney and liver\nexperimental_model: Rat cDNA transporters expressed in Xenopus oocytes; mammalian tissue distribution\nlimitations: Primary abstract only; no inferred human kinetic constants.\nexposure: Tissue-distribution analysis\ncross_nutrient: false\n[tsukaguchi1999] A family of mammalian Na+-dependent L-ascorbic acid transporters. (1999). https://pubmed.ncbi.nlm.nih.gov/10331392/ DOI: 10.1038/19986","model_system":"Rat cDNA transporters expressed in Xenopus oocytes; mammalian tissue distribution","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [tsukaguchi1999] A family of mammalian Na+-dependent L-ascorbic acid transporters. (1999). https://pubmed.ncbi.nlm.nih.gov/10331392/ DOI: 10.1038/19986","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}