Component
Human organic anion transporter 1 / SLC22A6
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Steviol trans-stimulated labeled para-aminohippurate efflux in human OAT1-expressing Xenopus oocytes, supporting transporter-mediated steviol movement.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human cloned transporter in frog oocytes; 1 micromolar steviol trans-stimulation.
- limitations
- A heterologous transport assay is not a clinical renal clearance measurement.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- A renal transporter recognizes the aglycone.
- primary_references
- Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366
- transport_effect
- depends Inferred from trans-stimulation of a tracer's efflux, which shows movement without fixing its direction.
- transport_pool
- the cytosol across the basolateral membrane Inferred from trans-stimulation of a tracer's efflux, which shows movement without fixing its direction.
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 98–104
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human cloned transporter in frog oocytes; 1 micromolar steviol trans-stimulation. · source_derived_draft · unverified_draft
## stevia-oat1 A renal transporter recognizes the aglycone. Steviol trans-stimulated labeled para-aminohippurate efflux in human OAT1-expressing Xenopus oocytes, supporting transporter-mediated steviol movement. Model: Human cloned transporter in frog oocytes; 1 micromolar steviol trans-stimulation. Limitations: A heterologous transport assay is not a clinical renal clearance measurement. Evidence access: Primary abstract Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366
Complete structured claim and evidence
Where it participates (unsigned role)
Stevioside did not inhibit human OAT3-mediated estrone-sulfate uptake or OAT1-mediated para-aminohippurate uptake, whereas steviol did.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human OAT expression in Xenopus oocytes.
- limitations
- A negative uptake-inhibition assay does not rule out all other transporters.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- The parent sweetener and its metabolite do not share every transport interaction.
- primary_references
- Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 114–120
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human OAT expression in Xenopus oocytes. · source_derived_draft · unverified_draft
## stevia-parent-oat-null The parent sweetener and its metabolite do not share every transport interaction. Stevioside did not inhibit human OAT3-mediated estrone-sulfate uptake or OAT1-mediated para-aminohippurate uptake, whereas steviol did. Model: Human OAT expression in Xenopus oocytes. Limitations: A negative uptake-inhibition assay does not rule out all other transporters. Evidence access: Primary abstract Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). · 2005 · https://pubmed.ncbi.nlm.nih.gov/15644426/ · DOI 10.1124/jpet.104.080366
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.