Component

Retinoid X receptor family

RXR alpha, beta and gamma; distinct from RAR family.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. An RXR-selective agonist alone failed to induce mucin transcripts but enhanced a suboptimal RAR agonist response.

    Retinoid X receptor family → Retinoic acid receptor family source_derived_draftungraded
    Experimental context and source evidence
    evidence_locator
    Abstract
    experimental_model
    Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists.
    exposure
    Selective receptor agonists
    limitations
    No inference that 9-cis RA improves airway disease.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Homo sapiens
    plain_language
    Both partners can cooperate, with RAR activation required in this assay.
    primary_references
    [va-koo-1999] Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells (1999). https://pubmed.ncbi.nlm.nih.gov/10024510/ DOI: 10.1042/bj3380351
    tissue_or_cell_type
    Normal tracheobronchial epithelial cells

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1370–1381

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists. · source_derived_draft · unverified_draft

    ### va-sig-rxr-airway-cooperation An RXR-selective agonist alone failed to induce mucin transcripts but enhanced a suboptimal RAR agonist response. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both partners can cooperate, with RAR activation required in this assay. organism: Homo sapiens tissue_or_cell_type: Normal tracheobronchial epithelial cells experimental_model: Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists. limitations: No inference that 9-cis RA improves airway disease. evidence_locator: Abstract exposure: Selective receptor agonists [va-koo-1999] Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells (1999). https://pubmed.ncbi.nlm.nih.gov/10024510/ DOI: 10.1042/bj3380351
    Complete structured claim and evidence

What acts on it

  1. 9-cis RA bound the tested RXR preparation with high affinity and activated RXR-dependent reporter responses.

    9-cis-retinoic acid → Retinoid X receptor family source_derived_draftungraded
    Experimental context and source evidence
    evidence_locator
    Abstract
    experimental_model
    Receptor binding and cell transfection assays.
    exposure
    9-cis RA exposure
    limitations
    Its biochemical activity does not establish a universal physiological RXR ligand pool.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Recombinant/cultured-cell system
    plain_language
    The 9-cis isomer supplies a direct experimental RXR ligand.
    primary_references
    [va-heyman-1992] 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor (1992). https://pubmed.ncbi.nlm.nih.gov/1310260/ DOI: 10.1016/0092-8674(92)90479-v
    tissue_or_cell_type
    Receptor-binding preparations

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1069–1080

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding and cell transfection assays. · source_derived_draft · unverified_draft

    ### va-sig-9cis-rxr-binding 9-cis RA bound the tested RXR preparation with high affinity and activated RXR-dependent reporter responses. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: The 9-cis isomer supplies a direct experimental RXR ligand. organism: Recombinant/cultured-cell system tissue_or_cell_type: Receptor-binding preparations experimental_model: Receptor binding and cell transfection assays. limitations: Its biochemical activity does not establish a universal physiological RXR ligand pool. evidence_locator: Abstract exposure: 9-cis RA exposure [va-heyman-1992] 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor (1992). https://pubmed.ncbi.nlm.nih.gov/1310260/ DOI: 10.1016/0092-8674(92)90479-v
    Complete structured claim and evidence

  2. All-trans RA did not effectively compete for RXR binding in the tested isomer assay.

    All-trans-retinoic acid → Retinoid X receptor family source_derived_draftungraded
    Experimental context and source evidence
    evidence_locator
    Abstract
    experimental_model
    Transfected COS-1 nucleosol; ligand competition and chimeric receptor reporters.
    exposure
    Isomer competition
    limitations
    Cell metabolism can alter apparent reporter responses.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Recombinant receptors in COS-1 cells
    plain_language
    RAR and RXR cannot be treated as interchangeable RA receptors.
    primary_references
    [va-allenby-1993] Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids (1993). https://pubmed.ncbi.nlm.nih.gov/8380496/ DOI: 10.1073/pnas.90.1.30
    tissue_or_cell_type
    Nuclear extracts

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1056–1067

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transfected COS-1 nucleosol; ligand competition and chimeric receptor reporters. · source_derived_draft · unverified_draft

    ### va-sig-atra-rxr-selectivity All-trans RA did not effectively compete for RXR binding in the tested isomer assay. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: RAR and RXR cannot be treated as interchangeable RA receptors. organism: Recombinant receptors in COS-1 cells tissue_or_cell_type: Nuclear extracts experimental_model: Transfected COS-1 nucleosol; ligand competition and chimeric receptor reporters. limitations: Cell metabolism can alter apparent reporter responses. evidence_locator: Abstract exposure: Isomer competition [va-allenby-1993] Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids (1993). https://pubmed.ncbi.nlm.nih.gov/8380496/ DOI: 10.1073/pnas.90.1.30
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards