{"id":"c605c1d1-4aa6-5e49-94f3-1f1b6ee6d6d8","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-rxr-airway-cooperation","predicate":"cooperates-with","statement":"An RXR-selective agonist alone failed to induce mucin transcripts but enhanced a suboptimal RAR agonist response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2f9c8372-4616-53ef-8fb2-3f6709cafca4","mechanism_event_label":"Both partners can cooperate, with RAR activation required in this assay.","subject":{"id":"bc49fbd3-6a7d-5cc4-9e4a-57aa0fa31928","slug":"rxr-family","display_name":"Retinoid X receptor family","entity_type_key":"protein_family"},"object":{"id":"0453bf0c-3c7c-5275-9b9e-8d7f01613b51","slug":"rar-family","display_name":"Retinoic acid receptor family","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"2f9c8372-4616-53ef-8fb2-3f6709cafca4","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-rxr-airway-cooperation-event","event_type":"biochemical_relationship","label":"Both partners can cooperate, with RAR activation required in this assay.","description":"An RXR-selective agonist alone failed to induce mucin transcripts but enhanced a suboptimal RAR agonist response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"nutrient-context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1f95782a-cdff-53e4-bafc-8887e45c626b","slug":"muc5ac-gene","display_name":"MUC5AC gene","entity_type_key":"gene"},"role":"transcript-readout","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bc49fbd3-6a7d-5cc4-9e4a-57aa0fa31928","slug":"rxr-family","display_name":"Retinoid X receptor family","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0453bf0c-3c7c-5275-9b9e-8d7f01613b51","slug":"rar-family","display_name":"Retinoic acid receptor family","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_locator","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Selective receptor agonists","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No inference that 9-cis RA improves airway disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Both partners can cooperate, with RAR activation required in this assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-koo-1999] Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells (1999). https://pubmed.ncbi.nlm.nih.gov/10024510/ DOI: 10.1042/bj3380351","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Normal tracheobronchial epithelial cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"22239c3d-afd4-507a-b914-f693372ef60a","evidence_kind":"source_excerpt","locator":"Lines 1370-1381","start_line":1370,"end_line":1381,"excerpt":"### va-sig-rxr-airway-cooperation\nAn RXR-selective agonist alone failed to induce mucin transcripts but enhanced a suboptimal RAR agonist response.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Both partners can cooperate, with RAR activation required in this assay.\norganism: Homo sapiens\ntissue_or_cell_type: Normal tracheobronchial epithelial cells\nexperimental_model: Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists.\nlimitations: No inference that 9-cis RA improves airway disease.\nevidence_locator: Abstract\nexposure: Selective receptor agonists\n[va-koo-1999] Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells (1999). https://pubmed.ncbi.nlm.nih.gov/10024510/ DOI: 10.1042/bj3380351","model_system":"Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-koo-1999] Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells (1999). https://pubmed.ncbi.nlm.nih.gov/10024510/ DOI: 10.1042/bj3380351","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}