Component

Renal hydrogen-potassium ATPase activities

Renal H+/K+-ATPases considered at the activity/family level when pharmacology does not identify a specific alpha subunit.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Luminal omeprazole abolished active net potassium absorption in the same potassium-restricted rabbit collecting-duct preparation.

    Renal hydrogen-potassium ATPase activities → Collecting duct potassium reabsorption source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    endpoint
    Luminal omeprazole abolished active net potassium absorption in the same potassium-restricted rabbit collecting-duct preparation.
    experimental-exposure
    Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM.
    experimental_model
    Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM.
    limitations
    Pharmacological activity assignment; the experiment does not isolate ATP4A versus ATP12A. Total-CO2 flux is an acidification surrogate.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Oryctolagus cuniculus
    plain_language
    The proton-pump-compatible activity also recovered potassium from tubular fluid.
    primary_references
    [wingo-1989-hka] Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase (1989). https://pubmed.ncbi.nlm.nih.gov/2544629/ DOI: 10.1172/JCI114165
    tissue_or_cell_type
    inner-stripe outer medullary collecting duct
    transport_direction
    potassium: tubular lumen toward blood; protons: cell toward tubular lumen
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1110–1122

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. · source_derived_draft · unverified_draft

    ### hka-sensitive-potassium-absorption Luminal omeprazole abolished active net potassium absorption in the same potassium-restricted rabbit collecting-duct preparation. Condition category: nutrient_deficiency nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The proton-pump-compatible activity also recovered potassium from tubular fluid. organism: Oryctolagus cuniculus tissue_or_cell_type: inner-stripe outer medullary collecting duct experimental_model: Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. limitations: Pharmacological activity assignment; the experiment does not isolate ATP4A versus ATP12A. Total-CO2 flux is an acidification surrogate. transport_direction: potassium: tubular lumen toward blood; protons: cell toward tubular lumen experimental-exposure: Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. endpoint: Luminal omeprazole abolished active net potassium absorption in the same potassium-restricted rabbit collecting-duct preparation. [wingo-1989-hka] Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase (1989). https://pubmed.ncbi.nlm.nih.gov/2544629/ DOI: 10.1172/JCI114165
    Complete structured claim and evidence

  2. Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits.

    Renal hydrogen-potassium ATPase activities → Collecting duct proton secretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    endpoint
    Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits.
    experimental-exposure
    Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM.
    experimental_model
    Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM.
    limitations
    Pharmacological activity assignment; the experiment does not isolate ATP4A versus ATP12A. Total-CO2 flux is an acidification surrogate.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Oryctolagus cuniculus
    plain_language
    An H/K-pump-compatible activity supported acid secretion in the isolated duct.
    primary_references
    [wingo-1989-hka] Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase (1989). https://pubmed.ncbi.nlm.nih.gov/2544629/ DOI: 10.1172/JCI114165
    tissue_or_cell_type
    inner-stripe outer medullary collecting duct
    transport_direction
    potassium: tubular lumen toward blood; protons: cell toward tubular lumen
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1096–1108

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. · source_derived_draft · unverified_draft

    ### hka-sensitive-proton-secretion Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits. Condition category: nutrient_deficiency nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: An H/K-pump-compatible activity supported acid secretion in the isolated duct. organism: Oryctolagus cuniculus tissue_or_cell_type: inner-stripe outer medullary collecting duct experimental_model: Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. limitations: Pharmacological activity assignment; the experiment does not isolate ATP4A versus ATP12A. Total-CO2 flux is an acidification surrogate. transport_direction: potassium: tubular lumen toward blood; protons: cell toward tubular lumen experimental-exposure: Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. endpoint: Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits. [wingo-1989-hka] Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase (1989). https://pubmed.ncbi.nlm.nih.gov/2544629/ DOI: 10.1172/JCI114165
    Complete structured claim and evidence

What acts on it

  1. Potassium depletion increased collecting-tubule potassium-stimulated, ouabain-insensitive ATPase activity in rats.

    Potassium → Renal hydrogen-potassium ATPase activities source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    endpoint
    Potassium depletion increased collecting-tubule potassium-stimulated, ouabain-insensitive ATPase activity in rats.
    experimental-exposure
    Microdissected rabbit nephron segments and collecting tubules of potassium-depleted rats.
    experimental_model
    Microdissected rabbit nephron segments and collecting tubules of potassium-depleted rats.
    limitations
    ATP hydrolysis and inhibitor sensitivity establish activity class, not a specific protein isoform or whole-animal flux.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Rattus norvegicus
    plain_language
    The distal kidney increased an ATP-consuming activity compatible with potassium recovery.
    primary_references
    [doucet-1987-hka] Characterization of K-ATPase activity in distal nephron: stimulation by potassium depletion (1987). https://pubmed.ncbi.nlm.nih.gov/2957926/ DOI: 10.1152/ajprenal.1987.253.3.F418
    tissue_or_cell_type
    collecting tubule
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1124–1135

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Microdissected rabbit nephron segments and collecting tubules of potassium-depleted rats. · source_derived_draft · unverified_draft

    ### k-depletion-increases-hka-activity Potassium depletion increased collecting-tubule potassium-stimulated, ouabain-insensitive ATPase activity in rats. Condition category: nutrient_deficiency nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The distal kidney increased an ATP-consuming activity compatible with potassium recovery. organism: Rattus norvegicus tissue_or_cell_type: collecting tubule experimental_model: Microdissected rabbit nephron segments and collecting tubules of potassium-depleted rats. limitations: ATP hydrolysis and inhibitor sensitivity establish activity class, not a specific protein isoform or whole-animal flux. experimental-exposure: Microdissected rabbit nephron segments and collecting tubules of potassium-depleted rats. endpoint: Potassium depletion increased collecting-tubule potassium-stimulated, ouabain-insensitive ATPase activity in rats. [doucet-1987-hka] Characterization of K-ATPase activity in distal nephron: stimulation by potassium depletion (1987). https://pubmed.ncbi.nlm.nih.gov/2957926/ DOI: 10.1152/ajprenal.1987.253.3.F418
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone.

    Potassium → Bicarbonate ion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Potassium and aldosterone-dependent sodium/acid handling jointly influence systemic bicarbonate.
    endpoint
    In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone.
    experimental-exposure
    Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement.
    experimental_model
    Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement.
    limitations
    Endocrine replacement experiment, not ordinary dietary deficiency; H/K-ATPase and H-ATPase were regulated differently.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Rattus norvegicus
    plain_language
    Potassium depletion and mineralocorticoid exposure can act together on renal acid handling.
    primary_references
    [eiam-1993-atpases] Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium (1993). https://pubmed.ncbi.nlm.nih.gov/8390478/ DOI: 10.1172/JCI116471
    tissue_or_cell_type
    collecting tubule and systemic blood
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1137–1149

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement. · source_derived_draft · unverified_draft

    ### k-aldosterone-joint-bicarbonate In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone. Condition category: nutrient_deficiency nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Potassium depletion and mineralocorticoid exposure can act together on renal acid handling. organism: Rattus norvegicus tissue_or_cell_type: collecting tubule and systemic blood experimental_model: Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement. limitations: Endocrine replacement experiment, not ordinary dietary deficiency; H/K-ATPase and H-ATPase were regulated differently. cross_nutrient: Potassium and aldosterone-dependent sodium/acid handling jointly influence systemic bicarbonate. experimental-exposure: Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement. endpoint: In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone. [eiam-1993-atpases] Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium (1993). https://pubmed.ncbi.nlm.nih.gov/8390478/ DOI: 10.1172/JCI116471
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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