Component
Collecting duct proton secretion
Luminal proton secretion, measured directly or by a specified total-CO2 flux surrogate.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- endpoint
- Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits.
- experimental-exposure
- Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM.
- experimental_model
- Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM.
- limitations
- Pharmacological activity assignment; the experiment does not isolate ATP4A versus ATP12A. Total-CO2 flux is an acidification surrogate.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Oryctolagus cuniculus
- plain_language
- An H/K-pump-compatible activity supported acid secretion in the isolated duct.
- primary_references
- [wingo-1989-hka] Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase (1989). https://pubmed.ncbi.nlm.nih.gov/2544629/ DOI: 10.1172/JCI114165
- tissue_or_cell_type
- inner-stripe outer medullary collecting duct
- transport_direction
- potassium: tubular lumen toward blood; protons: cell toward tubular lumen
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1096–1108
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. · source_derived_draft · unverified_draft
### hka-sensitive-proton-secretion Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits. Condition category: nutrient_deficiency nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: An H/K-pump-compatible activity supported acid secretion in the isolated duct. organism: Oryctolagus cuniculus tissue_or_cell_type: inner-stripe outer medullary collecting duct experimental_model: Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. limitations: Pharmacological activity assignment; the experiment does not isolate ATP4A versus ATP12A. Total-CO2 flux is an acidification surrogate. transport_direction: potassium: tubular lumen toward blood; protons: cell toward tubular lumen experimental-exposure: Microperfused inner-stripe outer medullary collecting ducts from rabbits fed 0.55% potassium diet for 7-14 days; luminal omeprazole 0.1 mM. endpoint: Luminal omeprazole abolished net total-CO2 flux used to measure acidification in collecting ducts from potassium-restricted rabbits. [wingo-1989-hka] Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase (1989). https://pubmed.ncbi.nlm.nih.gov/2544629/ DOI: 10.1172/JCI114165
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.