{"id":"9c28a0a4-bb3b-559e-92b7-3ed6e08f3ba1","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-aldosterone-joint-bicarbonate","predicate":"depletion-with-aldosterone-increases","statement":"In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a08bc2f7-b9e9-5273-9170-d52a96ea711b","mechanism_event_label":"Potassium depletion and mineralocorticoid exposure can act together on renal acid handling.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"edf44f6b-7b23-5b97-a86b-c940e5812b06","slug":"bicarbonate-ion","display_name":"Bicarbonate ion","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"a08bc2f7-b9e9-5273-9170-d52a96ea711b","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-aldosterone-joint-bicarbonate-event","event_type":"biochemical_relationship","label":"Potassium depletion and mineralocorticoid exposure can act together on renal acid handling.","description":"In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"upstream","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"edf44f6b-7b23-5b97-a86b-c940e5812b06","slug":"bicarbonate-ion","display_name":"Bicarbonate ion","entity_type_key":"ion"},"role":"downstream","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4ed6f3e2-76e5-577a-b3bb-64703cf550fa","slug":"aldosterone","display_name":"Aldosterone","entity_type_key":"small_molecule"},"role":"co-exposure","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"77a0b92b-ccdd-5ab2-a032-0ac8fc8f93d5","slug":"renal-hydrogen-potassium-atpases","display_name":"Renal hydrogen-potassium ATPase activities","entity_type_key":"protein_family"},"role":"regulated-machinery","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Potassium and aldosterone-dependent sodium/acid handling jointly influence systemic bicarbonate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental-exposure","value_text":"Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Endocrine replacement experiment, not ordinary dietary deficiency; H/K-ATPase and H-ATPase were regulated differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Potassium depletion and mineralocorticoid exposure can act together on renal acid handling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[eiam-1993-atpases] Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium (1993). https://pubmed.ncbi.nlm.nih.gov/8390478/ DOI: 10.1172/JCI116471","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"collecting tubule and systemic blood","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"67edc9a4-8d0e-533f-9040-cee465abc919","evidence_kind":"source_excerpt","locator":"Lines 1137-1149","start_line":1137,"end_line":1149,"excerpt":"### k-aldosterone-joint-bicarbonate\nIn adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone.\nCondition category: nutrient_deficiency\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Potassium depletion and mineralocorticoid exposure can act together on renal acid handling.\norganism: Rattus norvegicus\ntissue_or_cell_type: collecting tubule and systemic blood\nexperimental_model: Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement.\nlimitations: Endocrine replacement experiment, not ordinary dietary deficiency; H/K-ATPase and H-ATPase were regulated differently.\ncross_nutrient: Potassium and aldosterone-dependent sodium/acid handling jointly influence systemic bicarbonate.\nexperimental-exposure: Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement.\nendpoint: In adrenalectomized rats, low potassium combined with high aldosterone produced a larger serum-bicarbonate rise than either perturbation alone.\n[eiam-1993-atpases] Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium (1993). https://pubmed.ncbi.nlm.nih.gov/8390478/ DOI: 10.1172/JCI116471","model_system":"Glucocorticoid-replete adrenalectomized rats with varied dietary potassium and zero, physiological, or pharmacological aldosterone replacement.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [eiam-1993-atpases] Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium (1993). https://pubmed.ncbi.nlm.nih.gov/8390478/ DOI: 10.1172/JCI116471","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}