Component

Rat gastric vagal afferent activity

Context-specific entity; species, compartment and exposure are stated on each claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. MSG-evoked celiac vagal and adrenal splanchnic efferent responses were abolished by gastric vagotomy in rats.

    Rat gastric vagal afferent activity → Rat gastric glutamate-evoked autonomic reflex source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Anesthetized-rat intragastric infusion with gastric-branch vagotomy.
    limitations
    Nerve discharge is not direct measurement of a human hormonal or health benefit.
    nutrient_topic
    L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
    plain_language
    Cutting the sensory route interrupted the downstream reflex.
    primary_references
    Effects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z

    L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 74–80

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Anesthetized-rat intragastric infusion with gastric-branch vagotomy. · source_derived_draft · unverified_draft

    ## glutamate-gastric-reflex Cutting the sensory route interrupted the downstream reflex. MSG-evoked celiac vagal and adrenal splanchnic efferent responses were abolished by gastric vagotomy in rats. Model: Anesthetized-rat intragastric infusion with gastric-branch vagotomy. Limitations: Nerve discharge is not direct measurement of a human hormonal or health benefit. Evidence access: Primary full text Effects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z
    Complete structured claim and evidence

What acts on it

  1. Blocking 5-HT3 receptors prevented the rat gastric vagal response to luminal glutamate.

    Rat gastric 5-HT3 receptor activity, subunit composition unresolved → Rat gastric vagal afferent activity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Rat pharmacological blockade.
    limitations
    Subunits and an exclusive linear pathway are not established by the accessed abstract.
    nutrient_topic
    Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Monosodium L-glutamate
    plain_language
    A serotonin receptor relays part of the gut signal.
    primary_references
    Luminal amino acid sensing in the rat gastric mucosa. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16809638/ · DOI 10.1152/ajpgi.00587.2005
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20) · lines 162–168

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat pharmacological blockade. · source_derived_draft · unverified_draft

    ## monosodium-glutamate-5ht3-gate A serotonin receptor relays part of the gut signal. Blocking 5-HT3 receptors prevented the rat gastric vagal response to luminal glutamate. Model: Rat pharmacological blockade. Limitations: Subunits and an exclusive linear pathway are not established by the accessed abstract. Evidence access: Primary abstract Luminal amino acid sensing in the rat gastric mucosa. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16809638/ · DOI 10.1152/ajpgi.00587.2005
    Complete structured claim and evidence

  2. NOS inhibition blocked glutamate-evoked vagal firing; an NO donor mimicked firing and its response was blocked by 5-HT3 antagonism.

    Rat gastric nitric-oxide synthase activity, isoform unresolved → Rat gastric vagal afferent activity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Rat mucosal pharmacology.
    limitations
    Supports pathway ordering; not direct proof of each cell source or a human MSG–arginine interaction.
    nutrient_topic
    Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Monosodium L-glutamate
    plain_language
    Nitric oxide and serotonin signaling interact upstream of the nerve response.
    primary_references
    Luminal amino acid sensing in the rat gastric mucosa. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16809638/ · DOI 10.1152/ajpgi.00587.2005
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20) · lines 170–176

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat mucosal pharmacology. · source_derived_draft · unverified_draft

    ## monosodium-glutamate-nos-gate Nitric oxide and serotonin signaling interact upstream of the nerve response. NOS inhibition blocked glutamate-evoked vagal firing; an NO donor mimicked firing and its response was blocked by 5-HT3 antagonism. Model: Rat mucosal pharmacology. Limitations: Supports pathway ordering; not direct proof of each cell source or a human MSG–arginine interaction. Evidence access: Primary abstract Luminal amino acid sensing in the rat gastric mucosa. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16809638/ · DOI 10.1152/ajpgi.00587.2005
    Complete structured claim and evidence

  3. Serotonin depletion blocked glutamate-evoked gastric vagal firing in rats.

    Serotonin → Rat gastric vagal afferent activity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Rat gastric nutrient-sensing experiment.
    limitations
    Does not establish dietary tryptophan depletion from MSG or a human clinical syndrome.
    nutrient_topic
    Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Monosodium L-glutamate
    plain_language
    A locally available mediator was required in the tested pathway.
    primary_references
    Luminal amino acid sensing in the rat gastric mucosa. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16809638/ · DOI 10.1152/ajpgi.00587.2005
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20) · lines 154–160

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat gastric nutrient-sensing experiment. · source_derived_draft · unverified_draft

    ## monosodium-glutamate-serotonin-gate A locally available mediator was required in the tested pathway. Serotonin depletion blocked glutamate-evoked gastric vagal firing in rats. Model: Rat gastric nutrient-sensing experiment. Limitations: Does not establish dietary tryptophan depletion from MSG or a human clinical syndrome. Evidence access: Primary abstract Luminal amino acid sensing in the rat gastric mucosa. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16809638/ · DOI 10.1152/ajpgi.00587.2005
    Complete structured claim and evidence

  4. Intragastric 150 mM MSG increased gastric vagal afferent discharge in anesthetized rats.

    Monosodium L-glutamate → Rat gastric vagal afferent activity source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Anesthetized rats; 2 mL intragastric infusion at 1 mL/min, nerve discharge assessed after infusion.
    limitations
    MSG was the exposure; human food intake and subjective effects were not tested.
    nutrient_topic
    L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
    plain_language
    Glutamate in the stomach can signal through nerves without first acting at a brain glutamate receptor.
    primary_references
    Effects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z

    L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 66–72

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Anesthetized rats; 2 mL intragastric infusion at 1 mL/min, nerve discharge assessed after infusion. · source_derived_draft · unverified_draft

    ## glutamate-gastric-vagal Glutamate in the stomach can signal through nerves without first acting at a brain glutamate receptor. Intragastric 150 mM MSG increased gastric vagal afferent discharge in anesthetized rats. Model: Anesthetized rats; 2 mL intragastric infusion at 1 mL/min, nerve discharge assessed after infusion. Limitations: MSG was the exposure; human food intake and subjective effects were not tested. Evidence access: Primary full text Effects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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