{"id":"bcd53309-ce1f-5907-b4d6-4291aea54ba1","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-gastric-reflex","predicate":"supports","statement":"MSG-evoked celiac vagal and adrenal splanchnic efferent responses were abolished by gastric vagotomy in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"046229f9-185b-5fdd-93d4-082a8180e650","mechanism_event_label":"Cutting the sensory route interrupted the downstream reflex.","subject":{"id":"9bbf53ef-18a7-56bc-b4d2-dfbf898ce61e","slug":"rat-gastric-vagal-afferent-activity","display_name":"Rat gastric vagal afferent activity","entity_type_key":"cellular_process"},"object":{"id":"02d3b555-bfdd-504b-89cb-e9fe45479ecd","slug":"rat-gastric-glutamate-autonomic-reflex","display_name":"Rat gastric glutamate-evoked autonomic reflex","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"046229f9-185b-5fdd-93d4-082a8180e650","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-gastric-reflex-event","event_type":"observed_relationship","label":"Cutting the sensory route interrupted the downstream reflex.","description":"MSG-evoked celiac vagal and adrenal splanchnic efferent responses were abolished by gastric vagotomy in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9bbf53ef-18a7-56bc-b4d2-dfbf898ce61e","slug":"rat-gastric-vagal-afferent-activity","display_name":"Rat gastric vagal afferent activity","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"02d3b555-bfdd-504b-89cb-e9fe45479ecd","slug":"rat-gastric-glutamate-autonomic-reflex","display_name":"Rat gastric glutamate-evoked autonomic reflex","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Anesthetized-rat intragastric infusion with gastric-branch vagotomy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nerve discharge is not direct measurement of a human hormonal or health benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cutting the sensory route interrupted the downstream reflex.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8775991a-c591-5cc3-aec0-80b038bb65fd","evidence_kind":"source_excerpt","locator":"Lines 74-80","start_line":74,"end_line":80,"excerpt":"## glutamate-gastric-reflex\nCutting the sensory route interrupted the downstream reflex.\nMSG-evoked celiac vagal and adrenal splanchnic efferent responses were abolished by gastric vagotomy in rats.\nModel: Anesthetized-rat intragastric infusion with gastric-branch vagotomy.\nLimitations: Nerve discharge is not direct measurement of a human hormonal or health benefit.\nEvidence access: Primary full text\nEffects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z","model_system":"Anesthetized-rat intragastric infusion with gastric-branch vagotomy.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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