{"id":"ffb38019-87e5-521e-9812-fe0f636d8d9c","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-gastric-vagal","predicate":"increases","statement":"Intragastric 150 mM MSG increased gastric vagal afferent discharge in anesthetized rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4be018b0-a071-5e24-aa94-e2617c44d592","mechanism_event_label":"Glutamate in the stomach can signal through nerves without first acting at a brain glutamate receptor.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"9bbf53ef-18a7-56bc-b4d2-dfbf898ce61e","slug":"rat-gastric-vagal-afferent-activity","display_name":"Rat gastric vagal afferent activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4be018b0-a071-5e24-aa94-e2617c44d592","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-gastric-vagal-event","event_type":"observed_relationship","label":"Glutamate in the stomach can signal through nerves without first acting at a brain glutamate receptor.","description":"Intragastric 150 mM MSG increased gastric vagal afferent discharge in anesthetized rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9bbf53ef-18a7-56bc-b4d2-dfbf898ce61e","slug":"rat-gastric-vagal-afferent-activity","display_name":"Rat gastric vagal afferent activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Anesthetized rats; 2 mL intragastric infusion at 1 mL/min, nerve discharge assessed after infusion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"MSG was the exposure; human food intake and subjective effects were not tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Glutamate in the stomach can signal through nerves without first acting at a brain glutamate receptor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8bc1c378-a869-5d85-b894-fb98456bccac","evidence_kind":"source_excerpt","locator":"Lines 66-72","start_line":66,"end_line":72,"excerpt":"## glutamate-gastric-vagal\nGlutamate in the stomach can signal through nerves without first acting at a brain glutamate receptor.\nIntragastric 150 mM MSG increased gastric vagal afferent discharge in anesthetized rats.\nModel: Anesthetized rats; 2 mL intragastric infusion at 1 mL/min, nerve discharge assessed after infusion.\nLimitations: MSG was the exposure; human food intake and subjective effects were not tested.\nEvidence access: Primary full text\nEffects of intragastric infusion of inosine monophosphate and L: -glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21132420/ · DOI 10.1007/s12576-010-0121-z","model_system":"Anesthetized rats; 2 mL intragastric infusion at 1 mL/min, nerve discharge assessed after infusion.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c6a55239-e808-5ed7-9fa3-755a18ecb29f","stable_key":"import-b7014def-74ec-599e-8347-167e24fec1f0","title":"L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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