{"id":"bc52cde3-970e-5737-bf14-a84128a4ad18","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-serotonin-gate","predicate":"when_depleted_blocks","statement":"Serotonin depletion blocked glutamate-evoked gastric vagal firing in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d8f1acfd-d2c6-5a7e-a91b-c93132c0892c","mechanism_event_label":"A locally available mediator was required in the tested pathway.","subject":{"id":"fef9ecc3-7c04-553c-a207-d91e38a2665a","slug":"serotonin","display_name":"Serotonin","entity_type_key":"small_molecule"},"object":{"id":"9bbf53ef-18a7-56bc-b4d2-dfbf898ce61e","slug":"rat-gastric-vagal-afferent-activity","display_name":"Rat gastric vagal afferent activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d8f1acfd-d2c6-5a7e-a91b-c93132c0892c","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-serotonin-gate-event","event_type":"observed_relationship","label":"A locally available mediator was required in the tested pathway.","description":"Serotonin depletion blocked glutamate-evoked gastric vagal firing in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fef9ecc3-7c04-553c-a207-d91e38a2665a","slug":"serotonin","display_name":"Serotonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9bbf53ef-18a7-56bc-b4d2-dfbf898ce61e","slug":"rat-gastric-vagal-afferent-activity","display_name":"Rat gastric vagal afferent activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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