Component
Perinatal survival
Perinatal survival
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Providing Slc23a1-null pregnant mice 330 mg/L ascorbate in drinking water from mating to delivery prevented the excess perinatal mortality of their null offspring.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Slc23a1 knockout mice and wild-type controls
- exposure
- Slc23a1-null dams; 330 mg/L drinking-water ascorbate during pregnancy
- limitations
- Animal rescue dose; not a human dosing recommendation or correction of the deleted transporter.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Mus musculus
- plain_language
- Additional vitamin C rescued survival in this maternal transporter-loss model.
- primary_references
- [corpe2010] Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191
- tissue_or_cell_type
- Maternal-fetal system
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 182–193
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Slc23a1 knockout mice and wild-type controls · source_derived_draft · unverified_draft
### vc-transport-svct1-maternal-rescue Providing Slc23a1-null pregnant mice 330 mg/L ascorbate in drinking water from mating to delivery prevented the excess perinatal mortality of their null offspring. Condition category: machinery_impairment nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Additional vitamin C rescued survival in this maternal transporter-loss model. organism: Mus musculus tissue_or_cell_type: Maternal-fetal system experimental_model: Slc23a1 knockout mice and wild-type controls limitations: Animal rescue dose; not a human dosing recommendation or correction of the deleted transporter. exposure: Slc23a1-null dams; 330 mg/L drinking-water ascorbate during pregnancy cross_nutrient: false [corpe2010] Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191
Complete structured claim and evidencePups born to Slc23a1-null dams had approximately 45% perinatal mortality, including heterozygous and homozygous-null pups.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Slc23a1 knockout mice and wild-type controls
- exposure
- Breeding Slc23a1-null dams
- limitations
- Genotype of dam and pup must be distinguished; this does not define human pregnancy requirements.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Mus musculus
- plain_language
- Maternal loss of the renal vitamin C transporter threatened newborn survival.
- primary_references
- [corpe2010] Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191
- tissue_or_cell_type
- Maternal-fetal system
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 169–180
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Slc23a1 knockout mice and wild-type controls · source_derived_draft · unverified_draft
### vc-transport-svct1-maternal-survival Pups born to Slc23a1-null dams had approximately 45% perinatal mortality, including heterozygous and homozygous-null pups. Condition category: machinery_impairment nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Maternal loss of the renal vitamin C transporter threatened newborn survival. organism: Mus musculus tissue_or_cell_type: Maternal-fetal system experimental_model: Slc23a1 knockout mice and wild-type controls limitations: Genotype of dam and pup must be distinguished; this does not define human pregnancy requirements. exposure: Breeding Slc23a1-null dams cross_nutrient: false [corpe2010] Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191
Complete structured claim and evidenceSVCT2-null mice died within minutes of birth with respiratory failure and intraparenchymal brain hemorrhage.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- SVCT2-null mouse embryos, newborns and embryonic fibroblasts
- exposure
- Homozygous SVCT2 gene deletion
- limitations
- Multiorgan model; hemorrhage was not simply established as generalized scurvy, and individual lethal pathways were not isolated.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Mus musculus
- plain_language
- Severe loss of cellular vitamin C transport was lethal around birth in mice.
- primary_references
- [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
- tissue_or_cell_type
- Newborn brain and lung
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 221–232
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · SVCT2-null mouse embryos, newborns and embryonic fibroblasts · source_derived_draft · unverified_draft
### vc-transport-svct2-neonatal-phenotype SVCT2-null mice died within minutes of birth with respiratory failure and intraparenchymal brain hemorrhage. Condition category: machinery_impairment nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Severe loss of cellular vitamin C transport was lethal around birth in mice. organism: Mus musculus tissue_or_cell_type: Newborn brain and lung experimental_model: SVCT2-null mouse embryos, newborns and embryonic fibroblasts limitations: Multiorgan model; hemorrhage was not simply established as generalized scurvy, and individual lethal pathways were not isolated. exposure: Homozygous SVCT2 gene deletion cross_nutrient: false [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.