{"id":"10d6e290-b290-518f-89e7-173e6eee2ccc","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct1-maternal-rescue","predicate":"supplementation-improves","statement":"Providing Slc23a1-null pregnant mice 330 mg/L ascorbate in drinking water from mating to delivery prevented the excess perinatal mortality of their null offspring.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"930a6a21-d215-5ffe-a18d-55e451ecd228","mechanism_event_label":"Additional vitamin C rescued survival in this maternal transporter-loss model.","subject":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"object":{"id":"5bfb645e-530a-5cd0-9c13-4fbb910a404e","slug":"perinatal-survival","display_name":"Perinatal survival","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"930a6a21-d215-5ffe-a18d-55e451ecd228","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct1-maternal-rescue-event","event_type":"biochemical_relationship","label":"Additional vitamin C rescued survival in this maternal transporter-loss model.","description":"Providing Slc23a1-null pregnant mice 330 mg/L ascorbate in drinking water from mating to delivery prevented the excess perinatal mortality of their null offspring.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4dbabe1c-4ae0-5573-8ec8-38d8efa43e46","slug":"mouse-slc23a1-gene","display_name":"Mouse Slc23a1 gene","entity_type_key":"gene"},"role":"deleted machinery","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5bfb645e-530a-5cd0-9c13-4fbb910a404e","slug":"perinatal-survival","display_name":"Perinatal survival","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Slc23a1 knockout mice and wild-type controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Slc23a1-null dams; 330 mg/L drinking-water ascorbate during pregnancy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal rescue dose; not a human dosing recommendation or correction of the deleted transporter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Additional vitamin C rescued survival in this maternal transporter-loss model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[corpe2010] Vitamin C transporter Slc23a1 links renal   reabsorption, vitamin C tissue accumulation,   and perinatal survival in mice. 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