{"id":"33a714df-77b7-5bba-ac51-413154dbe95d","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct2-neonatal-phenotype","predicate":"deletion-reduces","statement":"SVCT2-null mice died within minutes of birth with respiratory failure and intraparenchymal brain hemorrhage.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7a2ffa21-00fc-55f3-b460-753699328a67","mechanism_event_label":"Severe loss of cellular vitamin C transport was lethal around birth in mice.","subject":{"id":"cdc19ebb-7348-5bd5-b0b1-87a95ecf822c","slug":"mouse-slc23a2-gene","display_name":"Mouse Slc23a2 gene","entity_type_key":"gene"},"object":{"id":"5bfb645e-530a-5cd0-9c13-4fbb910a404e","slug":"perinatal-survival","display_name":"Perinatal survival","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7a2ffa21-00fc-55f3-b460-753699328a67","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct2-neonatal-phenotype-event","event_type":"observed_intervention","label":"Severe loss of cellular vitamin C transport was lethal around birth in mice.","description":"SVCT2-null mice died within minutes of birth with respiratory failure and intraparenchymal brain hemorrhage.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"depleted vitamin","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cdc19ebb-7348-5bd5-b0b1-87a95ecf822c","slug":"mouse-slc23a2-gene","display_name":"Mouse Slc23a2 gene","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5bfb645e-530a-5cd0-9c13-4fbb910a404e","slug":"perinatal-survival","display_name":"Perinatal survival","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"SVCT2-null mouse embryos, newborns and embryonic fibroblasts","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Homozygous SVCT2 gene deletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Multiorgan model; hemorrhage was not simply established as generalized scurvy, and individual lethal pathways were not isolated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Severe loss of cellular vitamin C transport was lethal around birth in mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Newborn brain and lung","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"955a8f1f-c259-5b1b-82a6-5fc653b5f61d","evidence_kind":"source_excerpt","locator":"Lines 221-232","start_line":221,"end_line":232,"excerpt":"### vc-transport-svct2-neonatal-phenotype\nSVCT2-null mice died within minutes of birth with respiratory failure and intraparenchymal brain hemorrhage.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Severe loss of cellular vitamin C transport was lethal around birth in mice.\norganism: Mus musculus\ntissue_or_cell_type: Newborn brain and lung\nexperimental_model: SVCT2-null mouse embryos, newborns and embryonic fibroblasts\nlimitations: Multiorgan model; hemorrhage was not simply established as generalized scurvy, and individual lethal pathways were not isolated.\nexposure: Homozygous SVCT2 gene deletion\ncross_nutrient: false\n[sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514","model_system":"SVCT2-null mouse embryos, newborns and embryonic fibroblasts","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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