Component
Mouse Slc23a2 gene
Mouse gene encoding SVCT2; distinct from its protein. The SVCT2 gene was historically called Slc23a1 in Sotiriou 2002.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Embryonic fibroblasts from SVCT2-null mice retained less than 5% of normal ascorbic-acid uptake.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- SVCT2-null mouse embryos, newborns and embryonic fibroblasts
- exposure
- Homozygous SVCT2 gene deletion
- limitations
- Historical gene naming corrected to Slc23a2; abstract-limited assay details.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Mus musculus
- plain_language
- Without SVCT2, these embryonic cells took up very little reduced vitamin C.
- primary_references
- [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
- tissue_or_cell_type
- Embryonic fibroblasts
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 208–219
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · SVCT2-null mouse embryos, newborns and embryonic fibroblasts · source_derived_draft · unverified_draft
### vc-transport-svct2-fibroblast-loss Embryonic fibroblasts from SVCT2-null mice retained less than 5% of normal ascorbic-acid uptake. Condition category: machinery_impairment nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Without SVCT2, these embryonic cells took up very little reduced vitamin C. organism: Mus musculus tissue_or_cell_type: Embryonic fibroblasts experimental_model: SVCT2-null mouse embryos, newborns and embryonic fibroblasts limitations: Historical gene naming corrected to Slc23a2; abstract-limited assay details. exposure: Homozygous SVCT2 gene deletion cross_nutrient: false [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
Complete structured claim and evidenceSVCT2-null mice died within minutes of birth with respiratory failure and intraparenchymal brain hemorrhage.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- SVCT2-null mouse embryos, newborns and embryonic fibroblasts
- exposure
- Homozygous SVCT2 gene deletion
- limitations
- Multiorgan model; hemorrhage was not simply established as generalized scurvy, and individual lethal pathways were not isolated.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Mus musculus
- plain_language
- Severe loss of cellular vitamin C transport was lethal around birth in mice.
- primary_references
- [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
- tissue_or_cell_type
- Newborn brain and lung
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 221–232
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · SVCT2-null mouse embryos, newborns and embryonic fibroblasts · source_derived_draft · unverified_draft
### vc-transport-svct2-neonatal-phenotype SVCT2-null mice died within minutes of birth with respiratory failure and intraparenchymal brain hemorrhage. Condition category: machinery_impairment nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Severe loss of cellular vitamin C transport was lethal around birth in mice. organism: Mus musculus tissue_or_cell_type: Newborn brain and lung experimental_model: SVCT2-null mouse embryos, newborns and embryonic fibroblasts limitations: Multiorgan model; hemorrhage was not simply established as generalized scurvy, and individual lethal pathways were not isolated. exposure: Homozygous SVCT2 gene deletion cross_nutrient: false [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
Complete structured claim and evidence
Where it participates (unsigned role)
Maternal prenatal ascorbic-acid supplementation did not raise fetal blood ascorbate in SVCT2-null mouse fetuses.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- SVCT2-null mouse embryos, newborns and embryonic fibroblasts
- exposure
- Prenatal maternal supplementation with SVCT2-null fetuses
- limitations
- Supports a placental transport role but is not a placenta-specific deletion; dose is not resolved in the accessible abstract.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Mus musculus
- plain_language
- Increasing maternal supply did not overcome the fetus’s missing SVCT2 machinery.
- primary_references
- [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
- tissue_or_cell_type
- Placenta/fetal blood
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 234–245
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · SVCT2-null mouse embryos, newborns and embryonic fibroblasts · source_derived_draft · unverified_draft
### vc-transport-svct2-prenatal-nonrescue Maternal prenatal ascorbic-acid supplementation did not raise fetal blood ascorbate in SVCT2-null mouse fetuses. Condition category: machinery_impairment nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Increasing maternal supply did not overcome the fetus’s missing SVCT2 machinery. organism: Mus musculus tissue_or_cell_type: Placenta/fetal blood experimental_model: SVCT2-null mouse embryos, newborns and embryonic fibroblasts limitations: Supports a placental transport role but is not a placenta-specific deletion; dose is not resolved in the accessible abstract. exposure: Prenatal maternal supplementation with SVCT2-null fetuses cross_nutrient: false [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.