{"id":"e2300d26-ac46-566f-93f3-c2511271abdb","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct2-prenatal-nonrescue","predicate":"maternal-supplementation-does-not-raise","statement":"Maternal prenatal ascorbic-acid supplementation did not raise fetal blood ascorbate in SVCT2-null mouse fetuses.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"3beef82c-0b87-55f8-ab96-55484b0fe1d6","mechanism_event_label":"Increasing maternal supply did not overcome the fetus’s missing SVCT2 machinery.","subject":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"object":{"id":"a9088e94-6c25-5c52-a430-ff6da62bfc46","slug":"fetal-blood-ascorbate-concentration","display_name":"Fetal blood ascorbate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3beef82c-0b87-55f8-ab96-55484b0fe1d6","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct2-prenatal-nonrescue-event","event_type":"biochemical_relationship","label":"Increasing maternal supply did not overcome the fetus’s missing SVCT2 machinery.","description":"Maternal prenatal ascorbic-acid supplementation did not raise fetal blood ascorbate in SVCT2-null mouse fetuses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cdc19ebb-7348-5bd5-b0b1-87a95ecf822c","slug":"mouse-slc23a2-gene","display_name":"Mouse Slc23a2 gene","entity_type_key":"gene"},"role":"deleted machinery","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a9088e94-6c25-5c52-a430-ff6da62bfc46","slug":"fetal-blood-ascorbate-concentration","display_name":"Fetal blood ascorbate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"SVCT2-null mouse embryos, newborns and embryonic fibroblasts","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Prenatal maternal supplementation with SVCT2-null fetuses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Supports a placental transport role but is not a placenta-specific deletion; dose is not resolved in the accessible abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Increasing maternal supply did not overcome the fetus’s missing SVCT2 machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Placenta/fetal blood","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"76a538e9-270f-526f-a3a7-a38e108e356a","evidence_kind":"source_excerpt","locator":"Lines 234-245","start_line":234,"end_line":245,"excerpt":"### vc-transport-svct2-prenatal-nonrescue\nMaternal prenatal ascorbic-acid supplementation did not raise fetal blood ascorbate in SVCT2-null mouse fetuses.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Increasing maternal supply did not overcome the fetus’s missing SVCT2 machinery.\norganism: Mus musculus\ntissue_or_cell_type: Placenta/fetal blood\nexperimental_model: SVCT2-null mouse embryos, newborns and embryonic fibroblasts\nlimitations: Supports a placental transport role but is not a placenta-specific deletion; dose is not resolved in the accessible abstract.\nexposure: Prenatal maternal supplementation with SVCT2-null fetuses\ncross_nutrient: false\n[sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514","model_system":"SVCT2-null mouse embryos, newborns and embryonic fibroblasts","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sotiriou2002] Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. (2002). https://pubmed.ncbi.nlm.nih.gov/11984597/ DOI: 10.1038/0502-514","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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