{"id":"4453b7ae-08e1-5619-a052-8e5c8e41f620","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct1-maternal-survival","predicate":"maternal-deletion-reduces","statement":"Pups born to Slc23a1-null dams had approximately 45% perinatal mortality, including heterozygous and homozygous-null pups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9b209417-eb11-5db7-ac27-c724a31818a1","mechanism_event_label":"Maternal loss of the renal vitamin C transporter threatened newborn survival.","subject":{"id":"4dbabe1c-4ae0-5573-8ec8-38d8efa43e46","slug":"mouse-slc23a1-gene","display_name":"Mouse Slc23a1 gene","entity_type_key":"gene"},"object":{"id":"5bfb645e-530a-5cd0-9c13-4fbb910a404e","slug":"perinatal-survival","display_name":"Perinatal survival","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9b209417-eb11-5db7-ac27-c724a31818a1","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-svct1-maternal-survival-event","event_type":"observed_intervention","label":"Maternal loss of the renal vitamin C transporter threatened newborn survival.","description":"Pups born to Slc23a1-null dams had approximately 45% perinatal mortality, including heterozygous and homozygous-null pups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"maternal supply","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4dbabe1c-4ae0-5573-8ec8-38d8efa43e46","slug":"mouse-slc23a1-gene","display_name":"Mouse Slc23a1 gene","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5bfb645e-530a-5cd0-9c13-4fbb910a404e","slug":"perinatal-survival","display_name":"Perinatal survival","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Slc23a1 knockout mice and wild-type controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Breeding Slc23a1-null dams","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genotype of dam and pup must be distinguished; this does not define human pregnancy requirements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Maternal loss of the renal vitamin C transporter threatened newborn survival.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[corpe2010] Vitamin C transporter Slc23a1 links renal   reabsorption, vitamin C tissue accumulation,   and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Maternal-fetal system","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2149cb0b-d698-5a25-b3a8-9aa167d79347","evidence_kind":"source_excerpt","locator":"Lines 169-180","start_line":169,"end_line":180,"excerpt":"### vc-transport-svct1-maternal-survival\nPups born to Slc23a1-null dams had approximately 45% perinatal mortality, including heterozygous and homozygous-null pups.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Maternal loss of the renal vitamin C transporter threatened newborn survival.\norganism: Mus musculus\ntissue_or_cell_type: Maternal-fetal system\nexperimental_model: Slc23a1 knockout mice and wild-type controls\nlimitations: Genotype of dam and pup must be distinguished; this does not define human pregnancy requirements.\nexposure: Breeding Slc23a1-null dams\ncross_nutrient: false\n[corpe2010] Vitamin C transporter Slc23a1 links renal   reabsorption, vitamin C tissue accumulation,   and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191","model_system":"Slc23a1 knockout mice and wild-type controls","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [corpe2010] Vitamin C transporter Slc23a1 links renal   reabsorption, vitamin C tissue accumulation,   and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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