Component

Nifedipine

Nifedipine. Species, exposure and limitations are retained in each linked claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Nifedipine at 1 micromolar reduced cinnamaldehyde-induced islet calcium influx by approximately 26%.

    Nifedipine → Rat pancreatic-islet calcium influx source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/ceylon-research/37631083.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "81c61f935e3b9e0e16acb5e76bd56be59ca99bea4e3da001710e6d994abb92e7", "start_char": 15149, "end_char": 21214, "text_sha256": "472b3baeedfb72dc1405349207bce32da9e04cb33d20a481f90ef39269fe0c75"}
    experimental_model
    Rat glucose challenges and isolated intestinal/islet experiments
    exposure
    Cinnamaldehyde 5–20 mg/kg intraperitoneal in vivo; islet calcium experiment 100 micromolar for 10 minutes
    limitations
    Injection is not spice ingestion. Antagonists and calcium chelation probe machinery, not dietary mineral inadequacy.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Rat
    plain_language
    Blocking voltage-dependent calcium channels removed part of the response.
    primary_references
    [ceylon-p37631083] Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. (2023). https://pubmed.ncbi.nlm.nih.gov/37631083/ DOI: 10.3390/ph16081167
    tissue_or_cell_type
    Intestine and pancreatic islets
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 454–465

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat glucose challenges and isolated intestinal/islet experiments · source_derived_draft · unverified_draft

    ### ceylon-vdcc-block Nifedipine at 1 micromolar reduced cinnamaldehyde-induced islet calcium influx by approximately 26%. Condition category: machinery_impairment nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blocking voltage-dependent calcium channels removed part of the response. organism: Rat tissue_or_cell_type: Intestine and pancreatic islets experimental_model: Rat glucose challenges and isolated intestinal/islet experiments limitations: Injection is not spice ingestion. Antagonists and calcium chelation probe machinery, not dietary mineral inadequacy. exposure: Cinnamaldehyde 5–20 mg/kg intraperitoneal in vivo; islet calcium experiment 100 micromolar for 10 minutes evidence_span: {"source_cache": "artifacts/ceylon-research/37631083.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "81c61f935e3b9e0e16acb5e76bd56be59ca99bea4e3da001710e6d994abb92e7", "start_char": 15149, "end_char": 21214, "text_sha256": "472b3baeedfb72dc1405349207bce32da9e04cb33d20a481f90ef39269fe0c75"} [ceylon-p37631083] Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. (2023). https://pubmed.ncbi.nlm.nih.gov/37631083/ DOI: 10.3390/ph16081167
    Complete structured claim and evidence

  2. L-type calcium-channel blockade with 10 micromolar nifedipine exacerbated death during copper/myricetin exposure.

    Nifedipine → Human SH-SY5Y death under copper exposure source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Human SH-SY5Y pharmacological perturbation.
    limitations
    Channel subtype and causal downstream steps were not resolved; no human medication interaction established.
    nutrient_topic
    Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
    plain_language
    Changing calcium entry altered the response.
    primary_references
    Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33562817/ · DOI 10.3390/molecules26040845
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 364–370

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human SH-SY5Y pharmacological perturbation. · source_derived_draft · unverified_draft

    ## myricetin-copper-nifedipine Changing calcium entry altered the response. L-type calcium-channel blockade with 10 micromolar nifedipine exacerbated death during copper/myricetin exposure. Model: Human SH-SY5Y pharmacological perturbation. Limitations: Channel subtype and causal downstream steps were not resolved; no human medication interaction established. Evidence access: Primary full text Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33562817/ · DOI 10.3390/molecules26040845
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Heart rate increased by about 3.9 beats/minute during the melatonin period.

    Melatonin → Heart rate source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/10792199.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b", "start_char": 0, "end_char": 1482, "text_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b"}
    experimental_model
    Double-blind crossover drug-context trial
    exposure
    5 mg melatonin nightly for four weeks; nifedipine GITS 30 or 60 mg daily
    limitations
    Observed drug-context effect. The authors proposed competition, but a specific transporter, CYP interaction or calcium-channel mechanism was not proven.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    47 hypertensive patients stable on nifedipine
    plain_language
    This outcome is retained separately from the blood-pressure finding.
    primary_references
    [melatonin-p10792199] Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. (2000). https://pubmed.ncbi.nlm.nih.gov/10792199/ DOI: 10.1046/j.1365-2125.2000.00195.x
    tissue_or_cell_type
    Ambulatory blood pressure and heart rate

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 1046–1057

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind crossover drug-context trial · source_derived_draft · unverified_draft

    ### melatonin-nifedipine-heart-rate Heart rate increased by about 3.9 beats/minute during the melatonin period. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This outcome is retained separately from the blood-pressure finding. organism: 47 hypertensive patients stable on nifedipine tissue_or_cell_type: Ambulatory blood pressure and heart rate experimental_model: Double-blind crossover drug-context trial limitations: Observed drug-context effect. The authors proposed competition, but a specific transporter, CYP interaction or calcium-channel mechanism was not proven. exposure: 5 mg melatonin nightly for four weeks; nifedipine GITS 30 or 60 mg daily evidence_span: {"source_cache": "artifacts/melatonin-research/10792199.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b", "start_char": 0, "end_char": 1482, "text_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b"} [melatonin-p10792199] Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. (2000). https://pubmed.ncbi.nlm.nih.gov/10792199/ DOI: 10.1046/j.1365-2125.2000.00195.x
    Complete structured claim and evidence

  2. With nifedipine therapy, melatonin increased 24-hour systolic/diastolic pressure by about 6.5/4.9 mmHg.

    Melatonin → Arterial blood pressure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/10792199.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b", "start_char": 0, "end_char": 1482, "text_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b"}
    experimental_model
    Double-blind crossover drug-context trial
    exposure
    5 mg melatonin nightly for four weeks; nifedipine GITS 30 or 60 mg daily
    limitations
    Observed drug-context effect. The authors proposed competition, but a specific transporter, CYP interaction or calcium-channel mechanism was not proven.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    47 hypertensive patients stable on nifedipine
    plain_language
    A favorable reputation for one pathway does not guarantee the same response with a particular medicine.
    primary_references
    [melatonin-p10792199] Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. (2000). https://pubmed.ncbi.nlm.nih.gov/10792199/ DOI: 10.1046/j.1365-2125.2000.00195.x
    tissue_or_cell_type
    Ambulatory blood pressure and heart rate

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 1033–1044

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind crossover drug-context trial · source_derived_draft · unverified_draft

    ### melatonin-nifedipine-pressure With nifedipine therapy, melatonin increased 24-hour systolic/diastolic pressure by about 6.5/4.9 mmHg. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A favorable reputation for one pathway does not guarantee the same response with a particular medicine. organism: 47 hypertensive patients stable on nifedipine tissue_or_cell_type: Ambulatory blood pressure and heart rate experimental_model: Double-blind crossover drug-context trial limitations: Observed drug-context effect. The authors proposed competition, but a specific transporter, CYP interaction or calcium-channel mechanism was not proven. exposure: 5 mg melatonin nightly for four weeks; nifedipine GITS 30 or 60 mg daily evidence_span: {"source_cache": "artifacts/melatonin-research/10792199.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b", "start_char": 0, "end_char": 1482, "text_sha256": "71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b"} [melatonin-p10792199] Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. (2000). https://pubmed.ncbi.nlm.nih.gov/10792199/ DOI: 10.1046/j.1365-2125.2000.00195.x
    Complete structured claim and evidence

  3. One 600 mg LipoCol Forte capsule did not significantly change the measured pharmacokinetics of 5 mg nifedipine in 14 volunteers.

    LipoCol Forte red yeast rice preparation studied in 2012 → Human nifedipine plasma exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text PMC3513969
    experimental_model
    Human fasted-state single-dose pharmacokinetic comparison.
    limitations
    A null result for this dose does not exclude other drugs, preparations or exposures.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    The predicted enzyme interaction was not demonstrated in this tested regimen.
    primary_references
    [23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 156–162

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human fasted-state single-dose pharmacokinetic comparison. · source_derived_draft · unverified_draft

    ## red-yeast-rice-nifedipine-null The predicted enzyme interaction was not demonstrated in this tested regimen. One 600 mg LipoCol Forte capsule did not significantly change the measured pharmacokinetics of 5 mg nifedipine in 14 volunteers. Model: Human fasted-state single-dose pharmacokinetic comparison. Limitations: A null result for this dose does not exclude other drugs, preparations or exposures. Evidence access: Primary full text PMC3513969 [23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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