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(2023). https://pubmed.ncbi.nlm.nih.gov/37631083/ DOI: 10.3390/ph16081167","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine and pancreatic islets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"fc83de4a-9154-562a-ac42-8578e9669a56","evidence_kind":"source_excerpt","locator":"Lines 454-465","start_line":454,"end_line":465,"excerpt":"### ceylon-vdcc-block\nNifedipine at 1 micromolar reduced cinnamaldehyde-induced islet calcium influx by approximately 26%.\nCondition category: machinery_impairment\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Blocking voltage-dependent calcium channels removed part of the response.\norganism: Rat\ntissue_or_cell_type: Intestine and pancreatic islets\nexperimental_model: Rat glucose challenges and isolated intestinal/islet experiments\nlimitations: Injection is not spice ingestion. Antagonists and calcium chelation probe machinery, not dietary mineral inadequacy.\nexposure: Cinnamaldehyde 5–20 mg/kg intraperitoneal in vivo; islet calcium experiment 100 micromolar for 10 minutes\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/37631083.fulltext.txt\", \"locator\": \"Primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"81c61f935e3b9e0e16acb5e76bd56be59ca99bea4e3da001710e6d994abb92e7\", \"start_char\": 15149, \"end_char\": 21214, \"text_sha256\": \"472b3baeedfb72dc1405349207bce32da9e04cb33d20a481f90ef39269fe0c75\"}\n[ceylon-p37631083] Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. (2023). https://pubmed.ncbi.nlm.nih.gov/37631083/ DOI: 10.3390/ph16081167","model_system":"Rat glucose challenges and isolated intestinal/islet experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p37631083] Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. (2023). https://pubmed.ncbi.nlm.nih.gov/37631083/ DOI: 10.3390/ph16081167","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3aed3c5b-8016-5e37-ad6f-9019d34d19eb","stable_key":"import-3d41d18a-e13a-59a0-a081-55bfcdd43e55","title":"Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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