Component
Human SH-SY5Y death under copper exposure
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Myricetin exacerbated copper-associated cell death, corroborated by metabolic and trypan-blue measurements.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Human SH-SY5Y cells, 24 hours; 10 micrograms/mL myricetin is about 31.4 micromolar.
- limitations
- High copper cell-culture challenge; not evidence that ordinary copper foods plus myricetin cause neuronal injury.
- nutrient_topic
- Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
- plain_language
- Copper changes the outcome of this redox-active compound.
- primary_references
- Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33562817/ · DOI 10.3390/molecules26040845
Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 348–354
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human SH-SY5Y cells, 24 hours; 10 micrograms/mL myricetin is about 31.4 micromolar. · source_derived_draft · unverified_draft
## myricetin-copper-death Copper changes the outcome of this redox-active compound. Myricetin exacerbated copper-associated cell death, corroborated by metabolic and trypan-blue measurements. Model: Human SH-SY5Y cells, 24 hours; 10 micrograms/mL myricetin is about 31.4 micromolar. Limitations: High copper cell-culture challenge; not evidence that ordinary copper foods plus myricetin cause neuronal injury. Evidence access: Primary full text Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33562817/ · DOI 10.3390/molecules26040845
Complete structured claim and evidenceL-type calcium-channel blockade with 10 micromolar nifedipine exacerbated death during copper/myricetin exposure.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Human SH-SY5Y pharmacological perturbation.
- limitations
- Channel subtype and causal downstream steps were not resolved; no human medication interaction established.
- nutrient_topic
- Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
- plain_language
- Changing calcium entry altered the response.
- primary_references
- Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33562817/ · DOI 10.3390/molecules26040845
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 364–370
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human SH-SY5Y pharmacological perturbation. · source_derived_draft · unverified_draft
## myricetin-copper-nifedipine Changing calcium entry altered the response. L-type calcium-channel blockade with 10 micromolar nifedipine exacerbated death during copper/myricetin exposure. Model: Human SH-SY5Y pharmacological perturbation. Limitations: Channel subtype and causal downstream steps were not resolved; no human medication interaction established. Evidence access: Primary full text Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33562817/ · DOI 10.3390/molecules26040845
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.