{"id":"b1b1f857-077d-5dd9-8d6f-b069359d6b5b","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-nifedipine-pressure","predicate":"increases_with_nifedipine","statement":"With nifedipine therapy, melatonin increased 24-hour systolic/diastolic pressure by about 6.5/4.9 mmHg.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"638a0313-c3a0-5dc1-b3cc-4c09ea7124b3","mechanism_event_label":"A favorable reputation for one pathway does not guarantee the same response with a particular medicine.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"638a0313-c3a0-5dc1-b3cc-4c09ea7124b3","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-nifedipine-pressure-event","event_type":"observed_intervention","label":"A favorable reputation for one pathway does not guarantee the same response with a particular medicine.","description":"With nifedipine therapy, melatonin increased 24-hour systolic/diastolic pressure by about 6.5/4.9 mmHg.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1c59d504-7042-5922-b484-0819e3b9a93d","slug":"nifedipine","display_name":"Nifedipine","entity_type_key":"small_molecule"},"role":"background_medication","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/10792199.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind crossover drug-context trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"5 mg melatonin nightly for four weeks; nifedipine GITS 30 or 60 mg daily","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observed drug-context effect. The authors proposed competition, but a specific transporter, CYP interaction or calcium-channel mechanism was not proven.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"47 hypertensive patients stable on nifedipine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A favorable reputation for one pathway does not guarantee the same response with a particular medicine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p10792199] Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. (2000). https://pubmed.ncbi.nlm.nih.gov/10792199/ DOI: 10.1046/j.1365-2125.2000.00195.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ambulatory blood pressure and heart rate","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ef0264ce-cada-5d39-a91e-214128b0cf89","evidence_kind":"source_excerpt","locator":"Lines 1033-1044","start_line":1033,"end_line":1044,"excerpt":"### melatonin-nifedipine-pressure\nWith nifedipine therapy, melatonin increased 24-hour systolic/diastolic pressure by about 6.5/4.9 mmHg.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A favorable reputation for one pathway does not guarantee the same response with a particular medicine.\norganism: 47 hypertensive patients stable on nifedipine\ntissue_or_cell_type: Ambulatory blood pressure and heart rate\nexperimental_model: Double-blind crossover drug-context trial\nlimitations: Observed drug-context effect. The authors proposed competition, but a specific transporter, CYP interaction or calcium-channel mechanism was not proven.\nexposure: 5 mg melatonin nightly for four weeks; nifedipine GITS 30 or 60 mg daily\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/10792199.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"71e8d66126f1339089c1fda1bee67e6ceaf0afb4001d547741056521babf881b\"}\n[melatonin-p10792199] Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. (2000). https://pubmed.ncbi.nlm.nih.gov/10792199/ DOI: 10.1046/j.1365-2125.2000.00195.x","model_system":"Double-blind crossover drug-context trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p10792199] Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. (2000). https://pubmed.ncbi.nlm.nih.gov/10792199/ DOI: 10.1046/j.1365-2125.2000.00195.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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