Component

Mouse DMT1 (Slc11a2)

Mouse divalent metal transporter 1; not the human ortholog.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. DMT1-specific siRNA reduced apical manganese uptake in polarized mouse proximal-tubule cells.

    Mouse DMT1 (Slc11a2) → Cellular manganese uptake source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Transporter-specific siRNA in polarized mouse kidney proximal-tubule culture
    exposure
    DMT1 siRNA versus controls during apical manganese exposure.
    limitations
    Cell culture supports an uptake contribution; it does not quantify in vivo urinary reabsorption or rank transporter contributions.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Mus musculus
    plain_language
    DMT1 helped kidney-derived cells take up manganese from their lumen-facing side.
    primary_references
    [mn-trans-22534978] Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. (2012). https://pubmed.ncbi.nlm.nih.gov/22534978/ DOI: 10.1039/c2mt20024d
    tissue_or_cell_type
    Proximal-tubule epithelial cells, apical membrane
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 344–355

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter-specific siRNA in polarized mouse kidney proximal-tubule culture · source_derived_draft · unverified_draft

    ### mn-trans-renal-dmt1 DMT1-specific siRNA reduced apical manganese uptake in polarized mouse proximal-tubule cells. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: DMT1 helped kidney-derived cells take up manganese from their lumen-facing side. organism: Mus musculus tissue_or_cell_type: Proximal-tubule epithelial cells, apical membrane experimental_model: Transporter-specific siRNA in polarized mouse kidney proximal-tubule culture limitations: Cell culture supports an uptake contribution; it does not quantify in vivo urinary reabsorption or rank transporter contributions. exposure: DMT1 siRNA versus controls during apical manganese exposure. cross_nutrient: false [mn-trans-22534978] Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. (2012). https://pubmed.ncbi.nlm.nih.gov/22534978/ DOI: 10.1039/c2mt20024d
    Complete structured claim and evidence

What acts on it

  1. Expression of the iron importer DMT1 increased.

    Curcumin → Mouse DMT1 (Slc11a2) source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/24634837.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7", "start_char": 0, "end_char": 1451, "text_sha256": "3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7"}
    experimental_model
    Six-month feeding comparison in C57BL/6J mice
    exposure
    Diet containing 0.2% curcumin versus unsupplemented diet
    limitations
    Long-term mouse findings cannot be equated with acute human supplementation. Expression changes may be adaptive responses, not direct target binding.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Mus musculus
    plain_language
    Iron-handling machinery responded to the altered iron state.
    primary_references
    [curcumin-p24634837] Curcumin may impair iron status when fed to mice for six months. (2014). https://pubmed.ncbi.nlm.nih.gov/24634837/ DOI: 10.1016/j.redox.2014.01.018
    tissue_or_cell_type
    Liver and spleen

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 684–695

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-month feeding comparison in C57BL/6J mice · source_derived_draft · unverified_draft

    ### curcumin-mouse-dmt1 Expression of the iron importer DMT1 increased. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron-handling machinery responded to the altered iron state. organism: Mus musculus tissue_or_cell_type: Liver and spleen experimental_model: Six-month feeding comparison in C57BL/6J mice limitations: Long-term mouse findings cannot be equated with acute human supplementation. Expression changes may be adaptive responses, not direct target binding. exposure: Diet containing 0.2% curcumin versus unsupplemented diet evidence_span: {"source_cache": "artifacts/curcumin-research/24634837.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7", "start_char": 0, "end_char": 1451, "text_sha256": "3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7"} [curcumin-p24634837] Curcumin may impair iron status when fed to mice for six months. (2014). https://pubmed.ncbi.nlm.nih.gov/24634837/ DOI: 10.1016/j.redox.2014.01.018
    Complete structured claim and evidence

  2. Intestinal HIF-2alpha directly regulated DMT1 transcription and was required for iron balance; HIF-1alpha was not required for iron absorption in this study.

    Mouse hypoxia-inducible factor 2 alpha / Epas1 → Mouse DMT1 (Slc11a2) source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/iron-research/19352007.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040", "start_char": 0, "end_char": 1411, "text_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040"}
    experimental_model
    Conditional intestinal Hif1a/Hif2a knockout
    exposure
    Separate Hif1a versus Hif2a deletion
    limitations
    HIF isoforms were not interchangeable in this mouse experiment.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Mice
    plain_language
    The intestine uses a particular oxygen-responsive transcription factor to adjust its iron uptake machinery.
    primary_references
    [iron-p19352007] HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19352007/ DOI: 10.1172/jci38499
    tissue_or_cell_type
    Duodenal epithelium and systemic iron

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 849–860

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional intestinal Hif1a/Hif2a knockout · source_derived_draft · unverified_draft

    ### iron-hif2-dmt1 Intestinal HIF-2alpha directly regulated DMT1 transcription and was required for iron balance; HIF-1alpha was not required for iron absorption in this study. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The intestine uses a particular oxygen-responsive transcription factor to adjust its iron uptake machinery. organism: Mice tissue_or_cell_type: Duodenal epithelium and systemic iron experimental_model: Conditional intestinal Hif1a/Hif2a knockout limitations: HIF isoforms were not interchangeable in this mouse experiment. exposure: Separate Hif1a versus Hif2a deletion evidence_span: {"source_cache": "artifacts/iron-research/19352007.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040", "start_char": 0, "end_char": 1411, "text_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040"} [iron-p19352007] HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19352007/ DOI: 10.1172/jci38499
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards