Component

Mouse hypoxia-inducible factor 2 alpha / Epas1

Mouse hypoxia-inducible factor 2 alpha / Epas1. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Intestinal HIF-2alpha directly regulated DMT1 transcription and was required for iron balance; HIF-1alpha was not required for iron absorption in this study.

    Mouse hypoxia-inducible factor 2 alpha / Epas1 → Mouse DMT1 (Slc11a2) source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/iron-research/19352007.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040", "start_char": 0, "end_char": 1411, "text_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040"}
    experimental_model
    Conditional intestinal Hif1a/Hif2a knockout
    exposure
    Separate Hif1a versus Hif2a deletion
    limitations
    HIF isoforms were not interchangeable in this mouse experiment.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Mice
    plain_language
    The intestine uses a particular oxygen-responsive transcription factor to adjust its iron uptake machinery.
    primary_references
    [iron-p19352007] HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19352007/ DOI: 10.1172/jci38499
    tissue_or_cell_type
    Duodenal epithelium and systemic iron

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 849–860

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional intestinal Hif1a/Hif2a knockout · source_derived_draft · unverified_draft

    ### iron-hif2-dmt1 Intestinal HIF-2alpha directly regulated DMT1 transcription and was required for iron balance; HIF-1alpha was not required for iron absorption in this study. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The intestine uses a particular oxygen-responsive transcription factor to adjust its iron uptake machinery. organism: Mice tissue_or_cell_type: Duodenal epithelium and systemic iron experimental_model: Conditional intestinal Hif1a/Hif2a knockout limitations: HIF isoforms were not interchangeable in this mouse experiment. exposure: Separate Hif1a versus Hif2a deletion evidence_span: {"source_cache": "artifacts/iron-research/19352007.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040", "start_char": 0, "end_char": 1411, "text_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040"} [iron-p19352007] HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19352007/ DOI: 10.1172/jci38499
    Complete structured claim and evidence

  2. Intestinal Hif2a deletion lowered serum and liver iron and markedly reduced liver hepcidin expression.

    Mouse hypoxia-inducible factor 2 alpha / Epas1 → Serum iron concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/iron-research/19352007.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040", "start_char": 0, "end_char": 1411, "text_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040"}
    experimental_model
    Conditional intestinal Hif1a/Hif2a knockout
    exposure
    Separate Hif1a versus Hif2a deletion
    limitations
    HIF isoforms were not interchangeable in this mouse experiment.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Mice
    plain_language
    A hormonal attempt to increase iron availability did not replace the missing intestinal regulator.
    primary_references
    [iron-p19352007] HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19352007/ DOI: 10.1172/jci38499
    tissue_or_cell_type
    Duodenal epithelium and systemic iron
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 862–873

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional intestinal Hif1a/Hif2a knockout · source_derived_draft · unverified_draft

    ### iron-hif2-loss Intestinal Hif2a deletion lowered serum and liver iron and markedly reduced liver hepcidin expression. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A hormonal attempt to increase iron availability did not replace the missing intestinal regulator. organism: Mice tissue_or_cell_type: Duodenal epithelium and systemic iron experimental_model: Conditional intestinal Hif1a/Hif2a knockout limitations: HIF isoforms were not interchangeable in this mouse experiment. exposure: Separate Hif1a versus Hif2a deletion evidence_span: {"source_cache": "artifacts/iron-research/19352007.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040", "start_char": 0, "end_char": 1411, "text_sha256": "623fedcdd407c02879254b087510cff95b61336f7605c2430f51ab75ac550040"} [iron-p19352007] HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19352007/ DOI: 10.1172/jci38499
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards