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Expression changes may be adaptive responses, not direct target binding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Curcumin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Iron-handling machinery responded to the altered iron state.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[curcumin-p24634837] Curcumin may impair iron status when fed to mice for six months. (2014). https://pubmed.ncbi.nlm.nih.gov/24634837/ DOI: 10.1016/j.redox.2014.01.018","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver and spleen","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6e6112dc-86d9-500e-b97a-0dba163c165d","evidence_kind":"source_excerpt","locator":"Lines 684-695","start_line":684,"end_line":695,"excerpt":"### curcumin-mouse-dmt1\nExpression of the iron importer DMT1 increased.\nCondition category: normal\nnutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Iron-handling machinery responded to the altered iron state.\norganism: Mus musculus\ntissue_or_cell_type: Liver and spleen\nexperimental_model: Six-month feeding comparison in C57BL/6J mice\nlimitations: Long-term mouse findings cannot be equated with acute human supplementation. Expression changes may be adaptive responses, not direct target binding.\nexposure: Diet containing 0.2% curcumin versus unsupplemented diet\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/24634837.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7\", \"start_char\": 0, \"end_char\": 1451, \"text_sha256\": \"3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7\"}\n[curcumin-p24634837] Curcumin may impair iron status when fed to mice for six months. (2014). https://pubmed.ncbi.nlm.nih.gov/24634837/ DOI: 10.1016/j.redox.2014.01.018","model_system":"Six-month feeding comparison in C57BL/6J mice","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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